Definitions for linkage disequilibrium
link·age dis·e·qui·lib·ri·um

WiktionaryRate this definition:0.0 / 0 votes

1. linkage disequilibriumnoun

   A non-random association of two or more alleles at two or more loci; normally caused by an interaction between genes, and often illustrated on a pairwise linkage disequilibrium diagram (HapMap)

WikipediaRate this definition:0.0 / 0 votes

1. Linkage disequilibrium

   In population genetics, linkage disequilibrium (LD) is the non-random association of alleles at different loci in a given population. Loci are said to be in linkage disequilibrium when the frequency of association of their different alleles is higher or lower than what would be expected if the loci were independent and associated randomly.Linkage disequilibrium is influenced by many factors, including selection, the rate of genetic recombination, mutation rate, genetic drift, the system of mating, population structure, and genetic linkage. As a result, the pattern of linkage disequilibrium in a genome is a powerful signal of the population genetic processes that are structuring it. In spite of its name, linkage disequilibrium may exist between alleles at different loci without any genetic linkage between them and independently of whether or not allele frequencies are in equilibrium (not changing with time). Furthermore, linkage disequilibrium is sometimes referred to as gametic phase disequilibrium; however, the concept also applies to asexual organisms and therefore does not depend on the presence of gametes.

WikidataRate this definition:0.0 / 0 votes

1. Linkage disequilibrium

   In population genetics, linkage disequilibrium is the non-random association of alleles at two or more loci, that may or may not be on the same chromosome. It is also referred to as gametic phase disequilibrium, or simply gametic disequilibrium. In other words, linkage disequilibrium is the occurrence of some combinations of alleles or genetic markers in a population more often or less often than would be expected from a random formation of haplotypes from alleles based on their frequencies. It is a second order phenomenon derived from linkage, which is the presence of two or more loci on a chromosome with limited recombination between them. The amount of linkage disequilibrium depends on the difference between observed allelic frequencies and those expected from a homogenous, randomly distributed model. Populations where combinations of alleles or genotypes can be found in the expected proportions are said to be in linkage equilibrium. The level of linkage disequilibrium is influenced by a number of factors, including genetic linkage, selection, the rate of recombination, the rate of mutation, genetic drift, non-random mating, and population structure. A limiting example of the effect of rate of recombination may be seen in some organisms that reproduce asexually and hence exhibit no recombination to break down the linkage disequilibrium. An example of the effect of population structure is the phenomenon of Finnish disease heritage, which is attributed to a population bottleneck.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Linkage Disequilibrium

   Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.

How to pronounce linkage disequilibrium?

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How to say linkage disequilibrium in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of linkage disequilibrium in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of linkage disequilibrium in Pythagorean Numerology is: 2

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Linkage_Disequilibrium
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Linkage_Disequilibrium
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=linkage disequilibrium