Definitions for lewy body
lewy body

WiktionaryRate this definition:0.0 / 0 votes

1. Lewy bodynoun

   An abnormal aggregate of protein that develops inside nerve cells.

WikipediaRate this definition:0.0 / 0 votes

1. Lewy body

   Lewy bodies are the inclusion bodies – abnormal aggregations of protein – that develop inside nerve cells affected by Parkinson's disease (PD), the Lewy body dementias (Parkinson's disease dementia and dementia with Lewy bodies (DLB)), and some other disorders. They are also seen in cases of multiple system atrophy, particularly the parkinsonian variant (MSA-P).Lewy bodies appear as spherical masses in the cytoplasm that displace other cell components. For instance, some Lewy bodies tend to displace the nucleus to one side of the cell. There are two main kinds of Lewy bodies: classical and cortical. Lewy bodies may be found in the midbrain (within the substantia nigra) or within the cortex. A classical Lewy body is an eosinophilic cytoplasmic inclusion consisting of a dense core surrounded by a halo of 10-nm-wide radiating fibrils, the primary structural component of which is alpha-synuclein.

WikidataRate this definition:0.0 / 0 votes

1. Lewy body

   Lewy bodies are abnormal aggregates of protein that develop inside nerve cells in Parkinson's disease, Lewy body dementia and some other disorders. They are identified under the microscope when histology is performed on the brain. Lewy bodies appear as spherical masses that displace other cell components. The two morphological types are classical Lewy bodies and cortical Lewy bodies. A classical Lewy body is an eosinophilic cytoplasmic inclusion consisting of a dense core surrounded by a halo of 10-nm-wide radiating fibrils, the primary structural component of which is alpha-synuclein. In contrast, a cortical Lewy body is less well defined and lacks the halo. Nonetheless, it is still made up of alpha-synuclein fibrils. Cortical Lewy bodies are a distinguishing feature of Dementia with Lewy bodies, but may occasionally be seen in ballooned neurons characteristic of Pick's disease and corticobasal degeneration, as well as in patients with other tauopathies. They are also seen in cases of multiple system atrophy, particularly the Parkinsonian variant.

How to pronounce lewy body?

1. Alex

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   Mark

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   Daniel

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Numerology

1. Chaldean Numerology

   The numerical value of lewy body in Chaldean Numerology is: 2

2. Pythagorean Numerology

   The numerical value of lewy body in Pythagorean Numerology is: 3

Examples of lewy body in a Sentence

1. Susan Williams:

   Lewy body dementia killed Robin.

2. Piper Jaffray analyst Charles Duncan:

   Lewy body dementia is one of the most interesting, under-recognized disorders, i suspect you'll see Acadia go there too.

3. Susan Williams:

   Robin did not die from depression, robin had a deadly disease and it’s called Lewy body dementia. He had one of the worst cases they’d ever seen.

4. Schneider Williams:

   We're always learning more and more about the disease, from the basic science studies looking at cells and test tubes, to animal models, to human observational studies, to have diagnostics -- that can confirm in life that someone has Lewy body disease -- goes a long way both toward confirming the diagnosis and advancing research.

5. Schneider Williams:

   Lewy body is neurological; it's a circuitry problem. So the chemical and structural changes happening in Robin's brain were responsible for the psychiatric symptoms that he was experiencing.

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Lewy_Body
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Lewy_Body
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=lewy body