What does leptomycin mean?
Definitions for leptomycin
lep·to·mycin
This dictionary definitions page includes all the possible meanings, example usage and translations of the word leptomycin.
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Wiktionary
leptomycinnoun
Any of a family of antibiotics produced by Streptomyces bacteria
Wikidata
Leptomycin
Leptomycin B is a secondary metabolite produced by Streptomyces spp. Leptomycin B was originally discovered as a potent anti-fungal antibiotic. Leptomycin B was found to cause cell elongation of the fission yeast Schizosaccharomyces pombe. Since then this elongation effect has been used for the bioassay of leptomycin. However, recent data shows that Leptomycin causes G1 cell cycle arrest in mammalian cells and is a potent anti-tumor agent against murine experimental tumors in combination therapy. Leptomycin B has been shown to be a potent and specific nuclear export inhibitor in human and the fission yeast Schizosaccharomyces pombe. Leptomycin B alkylates and inhibits CRM1 /exportin 1, a protein required for nuclear export of proteins containing a nuclear export sequence, by glycosylating a cysteine residue. In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it inhibits the inactivation of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.
Numerology
Chaldean Numerology
The numerical value of leptomycin in Chaldean Numerology is: 5
Pythagorean Numerology
The numerical value of leptomycin in Pythagorean Numerology is: 6
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"leptomycin." Definitions.net. STANDS4 LLC, 2024. Web. 18 Apr. 2024. <https://www.definitions.net/definition/leptomycin>.
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