Janus kinase 1
JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain of type I cytokine receptors, to elicit signals from the IL-2 receptor family, the IL-4 receptor family, the gp130 receptor family. It is also important for transducing a signal by type I and type II interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.
U.S. National Library of Medicine
Janus Kinase 1
A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS.
The numerical value of janus kinase 1 in Chaldean Numerology is: 6
The numerical value of janus kinase 1 in Pythagorean Numerology is: 7
Images & Illustrations of janus kinase 1
Find a translation for the janus kinase 1 definition in other languages:
Select another language:
Discuss these janus kinase 1 definitions with the community:
Word of the Day
Would you like us to send you a FREE new word definition delivered to your inbox daily?
Use the citation below to add this definition to your bibliography:
"janus kinase 1." Definitions.net. STANDS4 LLC, 2018. Web. 18 Mar. 2018. <https://www.definitions.net/definition/janus kinase 1>.