Definitions for innexin
in·nex·in

WiktionaryRate this definition:0.0 / 0 votes

1. innexinnoun

   Any of a class of proteins used to create gap junctions in invertebrates.

WikipediaRate this definition:0.0 / 0 votes

1. Innexin

   Innexins are transmembrane proteins that form gap junctions in invertebrates. Gap junctions are composed of membrane proteins that form a channel permeable to ions and small molecules connecting the cytoplasm of adjacent cells. Although gap junctions provide similar functions in all multicellular organisms, it was not known what proteins invertebrates used for this purpose until the late 1990s. While the connexin family of gap junction proteins was well-characterized in vertebrates, no homologues were found in non-chordates. Innexins or related proteins are widespread among Eumetazoa, with the exception of echinoderms.

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1. Innexin

   An innexin is a member of a family of proteins that create gap junctions in invertebrates. The innexin proteins have four transmembrane spanning units and, like the vertebrate connexin gap junction protein, six innexin subunits together form a channel, an "innexon", in the plasma membrane between the inside and outside of the cell. Two innexons in apposed plasma membranes can form a gap junction. Innexin genes have homologues in vertebrates called pannexins. However, increasing evidence suggests that pannexons do not form gap junctions unless overexpressed in tissue. Thus, pannexins and innexins differ functionality and should be treated as separate families. These proteins have been named innexins. Gap junctions are composed of membrane proteins that form a channel permeable to ions and small molecules connecting the cytoplasm of adjacent cells. Although gap junctions provide similar functions in all multicellular organisms, until the late 1990s it was not known what proteins invertebrates used for this purpose. While the connexin family of gap junction proteins was well-characterised in vertebrates, no homologs were found in non-chordates. Gap junction molecules with no sequence homology to connexins were initially identified in fruit flies. It was suggested that these proteins are specific invertebrate gap junctions, and they were thus named "innexins". They were later identified in diverse invertebrates. Once the human genome was sequenced, innexin homologs were identified in humans and then in other vertebrates, indicating their ubiquitous distribution in the animal kingdom. They were called "pannexins".

How to pronounce innexin?

1. Alex

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   David

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   Mark

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   Daniel

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   Libby

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How to say innexin in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of innexin in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of innexin in Pythagorean Numerology is: 8

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Innexin
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Innexin
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=innexin