What does inhibitory concentration 50 mean?
Definitions for inhibitory concentration 50
in·hibitory con·cen·tration 50
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Wikipedia
inhibitory concentration 50
The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, in vitro, a given biological process or biological component by 50%. The biological component could be an enzyme, cell, cell receptor or microorganism. IC50 values are typically expressed as molar concentration. IC50 is commonly used as a measure of antagonist drug potency in pharmacological research. IC50 is comparable to other measures of potency, such as EC50 for excitatory drugs. EC50 represents the dose or plasma concentration required for obtaining 50% of a maximum effect in vivo.IC50 can be determined with functional assays or with competition binding assays. Sometimes, IC50 values are converted to the pIC50 scale. pIC 50 = − log 10 ( IC 50 ) {\displaystyle {\ce {pIC_{50}}}=-\log _{10}{\ce {(IC_{50})}}} Due to the minus sign, higher values of pIC50 indicate exponentially more potent inhibitors. pIC50 is usually given in terms of molar concentration (mol/L, or M), thus requiring IC50 in units of M.The IC50 terminology is also used for some behavioral measures in vivo, such as a two bottle fluid consumption test. When animals decrease consumption from the drug-laced water bottle, the concentration of the drug that results in a 50% decrease in consumption is considered the IC50 for fluid consumption of that drug.
U.S. National Library of Medicine
Inhibitory Concentration 50
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
Numerology
Chaldean Numerology
The numerical value of inhibitory concentration 50 in Chaldean Numerology is: 9
Pythagorean Numerology
The numerical value of inhibitory concentration 50 in Pythagorean Numerology is: 1
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"inhibitory concentration 50." Definitions.net. STANDS4 LLC, 2024. Web. 25 Apr. 2024. <https://www.definitions.net/definition/inhibitory+concentration+50>.
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