What does hyperkalemic periodic paralysis mean?
Definitions for hyperkalemic periodic paralysis
hy·per·kalemic pe·ri·od·ic para·ly·sis
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Wikipedia
Hyperkalemic periodic paralysis
Hyperkalemic periodic paralysis (HYPP, HyperKPP) is an inherited autosomal dominant disorder that affects sodium channels in muscle cells and the ability to regulate potassium levels in the blood. It is characterized by muscle hyperexcitability or weakness which, exacerbated by potassium, heat or cold, can lead to uncontrolled shaking followed by paralysis. Onset usually occurs in early childhood, but it still occurs with adults. The mutation which causes this disorder is dominant on SCN4A with linkage to the sodium channel expressed in muscle. The mutation causes single amino acid changes in parts of the channel which are important for inactivation. These mutations impair "ball and chain" fast inactivation of SCN4A following an action potential.
Wikidata
Hyperkalemic periodic paralysis
Hyperkalemic periodic paralysis is a genetic disorder that occurs in horses and humans, where it is also known as Impressive syndrome. It is an inherited autosomal dominant disorder that affects sodium channels in muscle cells and the ability to regulate potassium levels in the blood. It is most commonly associated with horses, but occurs in humans, where it may be called Gamstorp episodic adynamy. It is characterized by muscle hyperexcitability or weakness which, exacerbated by potassium or cold, can lead to uncontrolled shaking followed by paralysis. Onset in humans usually occurs in early childhood. The mutation which causes this disorder is dominant on SCN4A with linkage to the sodium channel expressed in muscle. The mutation causes single amino acid changes in parts of the channel which are important for inactivation. In the presence of high potassium levels, including those induced by diet, sodium channels fail to inactivate properly. Equine hyperkalaemic periodic paralysis occurs in 1 in 50 quarter horses and can be traced to a single ancestor, a stallion named Impressive.
Numerology
Chaldean Numerology
The numerical value of hyperkalemic periodic paralysis in Chaldean Numerology is: 4
Pythagorean Numerology
The numerical value of hyperkalemic periodic paralysis in Pythagorean Numerology is: 1
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"hyperkalemic periodic paralysis." Definitions.net. STANDS4 LLC, 2024. Web. 25 Apr. 2024. <https://www.definitions.net/definition/hyperkalemic+periodic+paralysis>.
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