Definitions for holoprosencephaly
holo·pros·en·cepha·ly

WiktionaryRate this definition:0.0 / 0 votes

1. holoprosencephalynoun

   A congenital disorder involving insufficient division of the lobes of the brain during fetal development, resulting in skull and facial deformities ranging from minor cleft lip problems to cyclopia, in which a single eye develops where the nose would normally be.

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1. Holoprosencephaly

   Holoprosencephaly is a cephalic disorder in which the prosencephalon fails to develop into two hemispheres. Normally, the forebrain is formed and the face begins to develop in the fifth and sixth weeks of human pregnancy. The condition also occurs in other species. The condition can be mild or severe. According to the National Institute of Neurological Disorders and Stroke, "in most cases of holoprosencephaly, the malformations are so severe that babies die before birth. When the embryo's forebrain does not divide to form bilateral cerebral hemispheres, it causes defects in the development of the face and in brain structure and function. In less severe cases, babies are born with normal or near-normal brain development and facial deformities that may affect the eyes, nose, and upper lip.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Holoprosencephaly

   Anterior midline brain, cranial, and facial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. Alobar prosencephaly is the most severe form and features anophthalmia; cyclopia; severe MENTAL RETARDATION; CLEFT LIP; CLEFT PALATE; SEIZURES; and microcephaly. Semilobar holoprosencepaly is characterized by hypotelorism, microphthalmia, coloboma, nasal malformations, and variable degrees of mental retardation. Lobar holoprosencephaly is associated with mild (or absent) facial malformations and intellectual abilities that range from mild mental retardation to normal. Holoprosencephaly is associated with CHROMOSOME ABNORMALITIES.

How to pronounce holoprosencephaly?

1. Alex

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   Daniel

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How to say holoprosencephaly in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of holoprosencephaly in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of holoprosencephaly in Pythagorean Numerology is: 9

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Holoprosencephaly
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=holoprosencephaly