What does hla-dr mean?
Definitions for hla-dr
hla-dr
This dictionary definitions page includes all the possible meanings, example usage and translations of the word hla-dr.
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Wikidata
HLA-DR
HLA-DR is a MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR and its ligand, a peptide of 9 amino acids in length or longer, constitutes a ligand for the T-cell receptor. HLA were originally defined as cell surface antigens that mediate graft-versus-host disease, which resulted in the rejection of tissue transplants in HLA-mismatched donors. Identification of these antigens has led to greater success and longevity in organ transplant. HLA-DR is also involved in several autoimmune conditions, disease susceptibility and disease resistance. It is also closely linked to HLA-DQ and this linkage often makes it difficult to resolve the more causative factor in disease. HLA-DR molecules are upregulated in response to signalling. In the instance of an infection, the peptide is bound into a DR molecule and presented to a few of a great many T-cell receptors found on T-helper cells. These cells then bind to antigens on the surface of B-cells stimulating B-cell proliferation.
Numerology
Chaldean Numerology
The numerical value of hla-dr in Chaldean Numerology is: 6
Pythagorean Numerology
The numerical value of hla-dr in Pythagorean Numerology is: 7
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"hla-dr." Definitions.net. STANDS4 LLC, 2024. Web. 7 Dec. 2024. <https://www.definitions.net/definition/hla-dr>.
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