Definitions for gene therapy
gene ther·a·py

WiktionaryRate this definition:0.0 / 0 votes

1. gene therapynoun

   Any of several therapies involving the insertion of genes into a patient's cells in order to replace defective ones

WikidataRate this definition:0.0 / 0 votes

1. Gene therapy

   Gene therapy is the use of DNA as a pharmaceutical agent to treat disease. It derives its name from the idea that DNA can be used to supplement or alter genes within an individual's cells as a therapy to treat disease. The most common form of gene therapy involves using DNA that encodes a functional, therapeutic gene to replace a mutated gene. Other forms involve directly correcting a mutation, or using DNA that encodes a therapeutic protein drug to provide treatment. In gene therapy, DNA that encodes a therapeutic protein is packaged within a "vector", which is used to get the DNA inside cells within the body. Once inside, the DNA becomes expressed by the cell machinery, resulting in the production of therapeutic protein, which in turn treats the patient's disease. Gene therapy was first conceptualized in 1972, with the authors urging caution before commencing gene therapy studies in humans. The first FDA-approved gene therapy experiment in the United States occurred in 1990, when Ashanti DeSilva was treated for ADA-SCID. Since then, over 1,700 clinical trials have been conducted using a number of techniques for gene therapy. Although early clinical failures led many to dismiss gene therapy as over-hyped, clinical successes in 2006–2013 have bolstered new optimism in the promise of gene therapy. These include successful treatment of patients with the retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia, acute lymphocytic leukemia, multiple myeloma and Parkinson's disease. These recent clinical successes have led to a renewed interest in gene therapy, with several articles in scientific and popular publications calling for continued investment in the field.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Gene Therapy

   The introduction of new genes into cells for the purpose of treating disease by restoring or adding gene expression. Techniques include insertion of retroviral vectors, transfection, homologous recombination, and injection of new genes into the nuclei of single cell embryos. The entire gene therapy process may consist of multiple steps. The new genes may be introduced into proliferating cells in vivo (e.g., bone marrow) or in vitro (e.g., fibroblast cultures) and the modified cells transferred to the site where the gene expression is required. Gene therapy may be particularly useful for treating enzyme deficiency diseases, hemoglobinopathies, and leukemias and may also prove useful in restoring drug sensitivity, particularly for leukemia.

How to pronounce gene therapy?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say gene therapy in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of gene therapy in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of gene therapy in Pythagorean Numerology is: 7

Examples of gene therapy in a Sentence

1. Jean Bennett:

   This could lead to the first approved gene therapy drug in the United States.

2. Eric Alton:

   Patients who received the gene therapy showed a significant, if modest, benefit in tests of lung function compared with the placebo group.

3. Ravindra Gupta:

   We need to understand if we could knock out this (CCR5) receptor in people with HIV, which may be possible with gene therapy.

4. Lonza CEO Marc Funk:

   Demand in gene therapy has increased, we believe this is going to continue in the coming years.

5. Severin Schwan:

   Our best guess is, it is complementary and that actually patients will need both options — a medicine like Hemlibra, and increasingly over time, gene therapy.

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Gene_Therapy
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=gene therapy