What does floxing mean?
Definitions for floxing
flox·ing
This dictionary definitions page includes all the possible meanings, example usage and translations of the word floxing.
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Wikidata
Floxing
In genetics, floxing refers to the sandwiching of a DNA sequence between two lox P sites. The terms are constructed upon the phrase "flanking/flanked by LoxP". Recombination between LoxP sites is catalysed by Cre recombinase. Floxing a gene allows it to be deleted, translocated or inverted in a process called Cre-Lox recombination. Floxed genes can also be used to produce organ-specific knockouts. For example, using the Cre recombinase with the alpha-myosin heavy chain promoter causes the floxed gene to be inactivated in the heart alone. Further, these knockouts can be inducible. In several mouse studies, tamoxifen is used to induce the Cre recombinase; in this case Cre is fused to a portion of the mouse estrogen receptor, which is naturally localized to the cytoplasm via its interactions with chaperone proteins such as heat shock protein 70 and 90. Tamoxifen binds to ER and disrupts its interactions with the chaperones. That allows the Cre-ER fusion protein to enter the nucleus and act on the floxed gene.
Numerology
Chaldean Numerology
The numerical value of floxing in Chaldean Numerology is: 5
Pythagorean Numerology
The numerical value of floxing in Pythagorean Numerology is: 6
Translations for floxing
From our Multilingual Translation Dictionary
- floxingGerman
- floscioItalian
- floxingPortuguese
- floxingRussian
- 花絮Chinese
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"floxing." Definitions.net. STANDS4 LLC, 2024. Web. 25 Apr. 2024. <https://www.definitions.net/definition/floxing>.
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