Definitions for dystrophin
dys·trophin

WiktionaryRate this definition:0.0 / 0 votes

1. dystrophinnoun

   A cytoplasmic structural protein that is deficient in some forms of muscular dystrophy

WikipediaRate this definition:0.0 / 0 votes

1. Dystrophin

   Dystrophin is a rod-shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane. This complex is variously known as the costamere or the dystrophin-associated protein complex (DAPC). Many muscle proteins, such as α-dystrobrevin, syncoilin, synemin, sarcoglycan, dystroglycan, and sarcospan, colocalize with dystrophin at the costamere. It has a molecular weight of 427 kDa Dystrophin is coded for by the DMD gene – the largest known human gene, covering 2.4 megabases (0.08% of the human genome) at locus Xp21. The primary transcript in muscle measures about 2,100 kilobases and takes 16 hours to transcribe; the mature mRNA measures 14.0 kilobases. The 79-exon muscle transcript codes for a protein of 3685 amino acid residues.Spontaneous or inherited mutations in the dystrophin gene can cause different forms of muscular dystrophy, a disease characterized by progressive muscular wasting. The most common of these disorders caused by genetic defects in dystrophin is Duchenne muscular dystrophy.

WikidataRate this definition:0.0 / 0 votes

1. Dystrophin

   Dystrophin is a rod-shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane. This complex is variously known as the costamere or the dystrophin-associated protein complex. Many muscle proteins, such as α-dystrobrevin, syncoilin, synemin, sarcoglycan, dystroglycan, and sarcospan, colocalize with dystrophin at the costamere. The dystrophin gene is one of the longest human genes known, covering 2.2 megabases at locus Xp21. The primary transcript measures about 2,400 kilobases and takes 16 hours to transcribe; the mature mRNA measures 14.0 kilobases. The 79 exons code for a protein of over 3500 amino acid residues.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Dystrophin

   A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.

Editors ContributionRate this definition:0.0 / 0 votes

1. dystrophin

   A form of protein.

   Dystrophin has a role in muscle structure in the human body.

   
   

   Submitted by MaryC on December 26, 2020  

How to pronounce dystrophin?

1. Alex

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How to say dystrophin in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of dystrophin in Chaldean Numerology is: 4

2. Pythagorean Numerology

   The numerical value of dystrophin in Pythagorean Numerology is: 4

Examples of dystrophin in a Sentence

1. Jerry Mendell:

   I have been waiting my entire 49-year career to find a therapy that dramatically reduces CK levels and creates significant levels of dystrophin.

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Dystrophin
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Dystrophin
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=dystrophin