Definitions for disulfiram
disul·fi·ram

Princeton's WordNetRate this definition:0.0 / 0 votes

1. disulfiram, Antabusenoun

   a drug (trade name Antabuse) used in the treatment of alcoholism; causes nausea and vomiting if alcohol is ingested

WiktionaryRate this definition:0.0 / 0 votes

1. disulfiramnoun

   A drug, 1-(diethylthiocarbamoyldisulfanyl)- N,N-diethyl-methanethioamide, used to treat chronic alcoholism

WikipediaRate this definition:0.0 / 0 votes

1. Disulfiram

   Disulfiram is a medication used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, causing many of the effects of a hangover to be felt immediately following alcohol consumption. Disulfiram plus alcohol, even small amounts, produces flushing, throbbing in the head and neck, a throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, fast heart rate, low blood pressure, fainting, marked uneasiness, weakness, vertigo, blurred vision, and confusion. In severe reactions there may be respiratory depression, cardiovascular collapse, abnormal heart rhythms, heart attack, acute congestive heart failure, unconsciousness, convulsions, and death.In the body, alcohol is converted to acetaldehyde, which is then broken down by acetaldehyde dehydrogenase. When the dehydrogenase enzyme is inhibited, acetaldehyde builds up, causing unpleasant side effects. Disulfiram should be used in conjunction with counseling and support.

ChatGPTRate this definition:0.0 / 0 votes

1. disulfiram

   Disulfiram is a medication used to treat chronic alcoholism by producing an acute sensitivity to alcohol. It works by interfering with the body's ability to metabolize alcohol, leading to unpleasant symptoms such as flushing, nausea, and palpitations when alcohol is consumed. This aims to discourage the individual from drinking. Disulfiram has been used as part of a comprehensive program for recovery from alcoholism for many years.

WikidataRate this definition:0.0 / 0 votes

1. Disulfiram

   Disulfiram is a drug discovered in the 1920s and used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. It blocks the processing of alcohol in the body by inhibiting acetaldehyde dehydrogenase thus causing an unpleasant reaction when alcohol is consumed. Disulfiram should be used in conjunction with counseling and support. Trade names for disulfiram in different countries are Antabuse and Antabus manufactured by Odyssey Pharmaceuticals. Disulfiram is also being studied as a treatment for cocaine dependence, as it prevents the breakdown of dopamine; the excess dopamine results in increased anxiety, higher blood pressure, restlessness and other unpleasant symptoms. Several studies have reported that it has anti-protozoal activity as well. Disulfiram is the subject of research for use in cancer therapy and as a treatment in HIV cure research.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Disulfiram

   A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.

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1. • Medicine

How to pronounce disulfiram?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say disulfiram in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of disulfiram in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of disulfiram in Pythagorean Numerology is: 4

Examples of disulfiram in a Sentence

1. Sharon Lewin:

   This trial clearly demonstrates that disulfiram is not toxic and is safe to use, and could quite possibly be the game changer we need, the dosage of disulfiram we used provided more of a tickle than a kick to the virus, but this could be enough. Even though the drug was only given for three days, we saw a clear increase in (the) virus in (the) plasma, which was very encouraging.

2. Sharon Lewin:

   This trial clearly demonstrates that disulfiram is not toxic and is safe to use, and could quite possibly be the game changer we need, the dosage of disulfiram we used provided more of a tickle than a kick to the virus, but this could be enough. Even though the drug was only given for three days, we saw a clear increase in( the) virus in( the) plasma, which was very encouraging.

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References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=disulfiram
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Disulfiram
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Disulfiram
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=disulfiram