What does deprotection mean?
Definitions for deprotection
de·pro·tec·tion
This dictionary definitions page includes all the possible meanings, example usage and translations of the word deprotection.
Wiktionary
deprotectionnoun
The removal of a protecting group when it is no longer needed.
Wikipedia
deprotection
A protecting group or protective group is introduced into a molecule by chemical modification of a functional group to obtain chemoselectivity in a subsequent chemical reaction. It plays an important role in multistep organic synthesis.In many preparations of delicate organic compounds, some specific parts of their molecules cannot survive the required reagents or chemical environments. Then, these parts, or groups, must be protected. For example, lithium aluminium hydride is a highly reactive but useful reagent capable of reducing esters to alcohols. It will always react with carbonyl groups, and this cannot be discouraged by any means. When a reduction of an ester is required in the presence of a carbonyl, the attack of the hydride on the carbonyl has to be prevented. For example, the carbonyl is converted into an acetal, which does not react with hydrides. The acetal is then called a protecting group for the carbonyl. After the step involving the hydride is complete, the acetal is removed (by reacting it with an aqueous acid), giving back the original carbonyl. This step is called deprotection. Protecting groups are more commonly used in small-scale laboratory work and initial development than in industrial production processes because their use adds additional steps and material costs to the process. However, the availability of a cheap chiral building block can overcome these additional costs (e.g. shikimic acid for oseltamivir).
Numerology
Chaldean Numerology
The numerical value of deprotection in Chaldean Numerology is: 1
Pythagorean Numerology
The numerical value of deprotection in Pythagorean Numerology is: 9
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Translations for deprotection
From our Multilingual Translation Dictionary
- suojauksen poistoFinnish
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"deprotection." Definitions.net. STANDS4 LLC, 2024. Web. 25 Apr. 2024. <https://www.definitions.net/definition/deprotection>.
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