Definitions for denosumab
deno·sum·ab

WiktionaryRate this definition:0.0 / 0 votes

1. denosumabnoun

   A human monoclonal antibody which is being studied in the treatment of bone disorders such as osteoporosis.

2. Etymology: Ad hoc prefix + -os- + -u- + -mab

WikipediaRate this definition:0.0 / 0 votes

1. Denosumab

   Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone.Denosumab is contraindicated in people with low blood calcium levels. The most common side effects are joint and muscle pain in the arms or legs.Denosumab is a inhibitor of RANKL (receptor activator of nuclear factor kappa-Β ligand), which works by decreasing the development of osteoclasts, which are cells that break down bone. It was developed by the biotechnology company Amgen.

WikidataRate this definition:0.0 / 0 votes

1. Denosumab

   Denosumab is a fully human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, bone metastases, rheumatoid arthritis, multiple myeloma, and giant cell tumor of bone. It was developed by the biotechnology company Amgen. Denosumab is designed to inhibit RANKL, a protein that acts as the primary signal for bone removal. In many bone loss conditions, RANKL overwhelms the body's natural defenses against bone destruction. In June 2010, denosumab was approved by the U.S. Food and Drug Administration for use in postmenopausal women with risk of osteoporosis under the trade name Prolia, and in November 2010, as Xgeva, for the prevention of skeleton-related events in patients with bone metastases from solid tumors. Denosumab is the first RANKL inhibitor to be approved by the FDA. In the summer of 2011 clinical trials were investigating denosumab in giant cell tumors, multiple myeloma with bone metastases, and hypercalcemia of malignancy, and further investigating its dosing and safety.

How to pronounce denosumab?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say denosumab in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of denosumab in Chaldean Numerology is: 1

2. Pythagorean Numerology

   The numerical value of denosumab in Pythagorean Numerology is: 4

Examples of denosumab in a Sentence

1. Robert McLean:

   Denosumab also decreases bone resorption by inhibiting maturation of osteoclasts through binding to a receptor on the surface of 'pre-osteoclast cells,'.

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Denosumab
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Denosumab
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=denosumab