What does cross-reactivity mean?
Definitions for cross-reactivity
cross-reac·tiv·i·ty
This dictionary definitions page includes all the possible meanings, example usage and translations of the word cross-reactivity.
Wiktionary
cross-reactivitynoun
The degree to which an antigen is effective against an antibody that was generated against a different antigen
Wikipedia
Cross-reactivity
Cross-reactivity, in a general sense, is the reactivity of an observed agent which initiates reactions outside the main reaction expected. This has implications for any kind of test or assay, including diagnostic tests in medicine, and can be a cause of false positives. In immunology, the definition of cross-reactivity refers specifically to the reaction of the immune system to antigens. There can be cross-reactivity between the immune system and the antigens of two different pathogens, or between one pathogen and proteins on non-pathogens, which in some cases can be the cause of allergies.
Wikidata
Cross-reactivity
Cross-reactivity applies to the reaction between two different species as opposed to the self-reactivity. In chemistry it means a reaction between two different molecules. At the same time each of these molecules is able to react with the identical molecule, or as it is usually described, to react with itself. In immunology, the cross-reactivity has a more narrow meaning of the reaction between an antibody and an antigen that differs from the immunogen. It is sometimes also referred to as crossimmunity or cross-protective immunity, although cross-reactivity does not necessarily infer cross-protection. A few examples of cross-reactivity have been confirmed in humans, one of which involves influenza virus-specific CD8+ T cell and hepatitis C virus antigens. An adaptive immune response is specific to the antigen that stimulated it. However, many naturally occurring 'antigens' are a mixture of macromolecules comprising several epitopes. Contact with a complex antigen such as a virus will stimulate multiple immune responses to the virus' different macromolecules as well as the individual epitopes of each macromolecule. For example, the tetanus toxin is a single protein macromolecular antigen but will stimulate many immune responses due to the tertiary structure of the protein yielding many different epitopes. The toxin that creates the immune response will have an epitope on it that stimulates the response. Denaturing the protein may 'disarm' its function but allow the immune system to have an immune response thus creating an immunity without harming the patient.
Numerology
Chaldean Numerology
The numerical value of cross-reactivity in Chaldean Numerology is: 1
Pythagorean Numerology
The numerical value of cross-reactivity in Pythagorean Numerology is: 8
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"cross-reactivity." Definitions.net. STANDS4 LLC, 2024. Web. 23 Apr. 2024. <https://www.definitions.net/definition/cross-reactivity>.
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