Definitions for costamere
costamere

WiktionaryRate this definition:0.0 / 0 votes

1. costamerenoun

   A structural-functional component of striated muscle cells.

WikipediaRate this definition:0.0 / 0 votes

1. Costamere

   The costamere is a structural-functional component of striated muscle cells which connects the sarcomere of the muscle to the cell membrane (i.e. the sarcolemma).Costameres are sub-sarcolemmal protein assemblies circumferentially aligned in register with the Z-disk of peripheral myofibrils. They physically couple force-generating sarcomeres with the sarcolemma in striated muscle cells and are thus considered one of several "Achilles' heels" of skeletal muscle, a critical component of striated muscle morphology which, when compromised, is thought to directly contribute to the development of several distinct myopathies.The dystrophin-associated protein complex, also referred to as the dystrophin-associated glycoprotein complex (DGC or DAGC), contains various integral and peripheral membrane proteins such as dystroglycans and sarcoglycans, which are thought to be responsible for linking the internal cytoskeletal system of individual myofibers to structural proteins within the extracellular matrix (such as collagen and laminin). Therefore, it is one of the features of the sarcolemma which helps to couple the sarcomere to the extracellular connective tissue as some experiments have shown. Desmin protein may also bind to the DAG complex, and regions of it are known to be involved in signaling.

WikidataRate this definition:0.0 / 0 votes

1. Costamere

   The costamere is a structural-functional component of striated muscle cells which connects the sarcomere of the muscle to the cell membrane. Costameres are sub-sarcolemmal protein assemblies circumferentially aligned in register with the Z-disk of peripheral myofibrils. They physically couple force-generating sarcomeres with the sarcolemma in striated muscle cells and are thus considered one of several "Achilles' heels" of skeletal muscle, a critical component of striated muscle morphology which, when compromised, is thought to directly contribute to the development of several distinct myopathies. The dystrophin-associated glycoprotein complex contains various integral and peripheral membrane proteins such as dystroglycans and sarcoglycans, which are thought to be responsible for linking the internal cytoskeletal system of individual myofibers to structural proteins within the extracellular matrix. Therefore it is one of the features of the sarcolemma which helps to couple the sarcomere to the extracellular connective tissue. Desmin protein may also bind to the DAG complex, and regions of it are known to be involved in signaling.

Editors ContributionRate this definition:0.0 / 0 votes

1. costamere

   Is a component of muscle.

   Costameres are a component of muscle.

   
   

   Submitted by MaryC on February 14, 2017  

How to pronounce costamere?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say costamere in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of costamere in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of costamere in Pythagorean Numerology is: 9

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Costamere
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Costamere
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=costamere