What does cleavage and polyadenylation specificity factor mean?
Definitions for cleavage and polyadenylation specificity factor
cleav·age and polyadeny·la·tion speci·fici·ty fac·tor
This dictionary definitions page includes all the possible meanings, example usage and translations of the word cleavage and polyadenylation specificity factor.
Wikipedia
Cleavage and polyadenylation specificity factor
Cleavage and polyadenylation specificity factor (CPSF) is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (pre-mRNA) molecule in the process of gene transcription. It is the first protein to bind to the signaling region near the cleavage site of the pre-mRNA, to which the poly(A) tail will be added by polynucleotide adenylyltransferase. The upstream signaling region has the canonical nucleotide sequence AAUAAA, which is highly conserved across the vast majority of pre-mRNAs. A second downstream signaling region, located on the portion of the pre-mRNA that is cleaved before polyadenylation, consists of a GU-rich region required for efficient processing.
Wikidata
Cleavage and polyadenylation specificity factor
Cleavage and polyadenylation specificity factor is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA molecule in the process of gene transcription. It is the first protein to bind to the signaling region near the cleavage site of the pre-mRNA, to which the polyadenine tail will be added by polyadenine polymerase. The upstream signaling region has the canonical nucleotide sequence AAUAAA, which is highly conserved across the vast majority of pre-mRNAs. A second downstream signaling region, located on the portion of the pre-mRNA that is cleaved before polyadenylation, consists of a GU-rich region required for efficient processing. CPSF is a protein complex consisting of four proteins: CPSF-73, CPSF-100, CPSF-30 and CPSF-160. CPSF-73 is believed to be the endonuclease which cleaves mRNA precursor and the crystal structure of its N-terminal domain has been resolved. CPSF recruits additional proteins to the 3' region. Identified proteins that are coordinated by CPSF activity include: cleavage stimulatory factor and the two poorly-understood cleavage factors. The binding of the polyadenine polymerase responsible for actually synthesizing the tail is a necessary prerequisite for cleavage, thus ensuring that cleavage and polyadenylation are tightly coupled processes.
U.S. National Library of Medicine
Cleavage And Polyadenylation Specificity Factor
An RNA-binding protein that recognizes the AAUAAA RNA SEQUENCE at the 3' end of MRNA. It contains four subunits of 30, 73, 100 and 160 kDa molecular size and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.
Numerology
Chaldean Numerology
The numerical value of cleavage and polyadenylation specificity factor in Chaldean Numerology is: 3
Pythagorean Numerology
The numerical value of cleavage and polyadenylation specificity factor in Pythagorean Numerology is: 9
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"cleavage and polyadenylation specificity factor." Definitions.net. STANDS4 LLC, 2024. Web. 28 Mar. 2024. <https://www.definitions.net/definition/cleavage+and+polyadenylation+specificity+factor>.
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