What does cleavage and polyadenylation specificity factor mean?

Definitions for cleavage and polyadenylation specificity factor
cleav·age and polyadeny·la·tion speci·fici·ty fac·tor

This dictionary definitions page includes all the possible meanings, example usage and translations of the word cleavage and polyadenylation specificity factor.

Wikipedia

  1. Cleavage and polyadenylation specificity factor

    Cleavage and polyadenylation specificity factor (CPSF) is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (pre-mRNA) molecule in the process of gene transcription. It is the first protein to bind to the signaling region near the cleavage site of the pre-mRNA, to which the poly(A) tail will be added by polynucleotide adenylyltransferase. The upstream signaling region has the canonical nucleotide sequence AAUAAA, which is highly conserved across the vast majority of pre-mRNAs. A second downstream signaling region, located on the portion of the pre-mRNA that is cleaved before polyadenylation, consists of a GU-rich region required for efficient processing.

Wikidata

  1. Cleavage and polyadenylation specificity factor

    Cleavage and polyadenylation specificity factor is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA molecule in the process of gene transcription. It is the first protein to bind to the signaling region near the cleavage site of the pre-mRNA, to which the polyadenine tail will be added by polyadenine polymerase. The upstream signaling region has the canonical nucleotide sequence AAUAAA, which is highly conserved across the vast majority of pre-mRNAs. A second downstream signaling region, located on the portion of the pre-mRNA that is cleaved before polyadenylation, consists of a GU-rich region required for efficient processing. CPSF is a protein complex consisting of four proteins: CPSF-73, CPSF-100, CPSF-30 and CPSF-160. CPSF-73 is believed to be the endonuclease which cleaves mRNA precursor and the crystal structure of its N-terminal domain has been resolved. CPSF recruits additional proteins to the 3' region. Identified proteins that are coordinated by CPSF activity include: cleavage stimulatory factor and the two poorly-understood cleavage factors. The binding of the polyadenine polymerase responsible for actually synthesizing the tail is a necessary prerequisite for cleavage, thus ensuring that cleavage and polyadenylation are tightly coupled processes.

U.S. National Library of Medicine

  1. Cleavage And Polyadenylation Specificity Factor

    An RNA-binding protein that recognizes the AAUAAA RNA SEQUENCE at the 3' end of MRNA. It contains four subunits of 30, 73, 100 and 160 kDa molecular size and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.

How to pronounce cleavage and polyadenylation specificity factor?

How to say cleavage and polyadenylation specificity factor in sign language?

Numerology

  1. Chaldean Numerology

    The numerical value of cleavage and polyadenylation specificity factor in Chaldean Numerology is: 3

  2. Pythagorean Numerology

    The numerical value of cleavage and polyadenylation specificity factor in Pythagorean Numerology is: 9

Translation

Find a translation for the cleavage and polyadenylation specificity factor definition in other languages:

Select another language:

  • - Select -
  • 简体中文 (Chinese - Simplified)
  • 繁體中文 (Chinese - Traditional)
  • Español (Spanish)
  • Esperanto (Esperanto)
  • 日本語 (Japanese)
  • Português (Portuguese)
  • Deutsch (German)
  • العربية (Arabic)
  • Français (French)
  • Русский (Russian)
  • ಕನ್ನಡ (Kannada)
  • 한국어 (Korean)
  • עברית (Hebrew)
  • Gaeilge (Irish)
  • Українська (Ukrainian)
  • اردو (Urdu)
  • Magyar (Hungarian)
  • मानक हिन्दी (Hindi)
  • Indonesia (Indonesian)
  • Italiano (Italian)
  • தமிழ் (Tamil)
  • Türkçe (Turkish)
  • తెలుగు (Telugu)
  • ภาษาไทย (Thai)
  • Tiếng Việt (Vietnamese)
  • Čeština (Czech)
  • Polski (Polish)
  • Bahasa Indonesia (Indonesian)
  • Românește (Romanian)
  • Nederlands (Dutch)
  • Ελληνικά (Greek)
  • Latinum (Latin)
  • Svenska (Swedish)
  • Dansk (Danish)
  • Suomi (Finnish)
  • فارسی (Persian)
  • ייִדיש (Yiddish)
  • հայերեն (Armenian)
  • Norsk (Norwegian)
  • English (English)

Word of the Day

Would you like us to send you a FREE new word definition delivered to your inbox daily?

Please enter your email address:


Citation

Use the citation below to add this definition to your bibliography:

Style:MLAChicagoAPA

"cleavage and polyadenylation specificity factor." Definitions.net. STANDS4 LLC, 2024. Web. 28 Mar. 2024. <https://www.definitions.net/definition/cleavage+and+polyadenylation+specificity+factor>.

Discuss these cleavage and polyadenylation specificity factor definitions with the community:

0 Comments

    Are we missing a good definition for cleavage and polyadenylation specificity factor? Don't keep it to yourself...

    Free, no signup required:

    Add to Chrome

    Get instant definitions for any word that hits you anywhere on the web!

    Free, no signup required:

    Add to Firefox

    Get instant definitions for any word that hits you anywhere on the web!

    Browse Definitions.net

    Quiz

    Are you a words master?

    »
    irregularly slashed and jagged as if torn
    A numinous
    B usurious
    C lacerate
    D bibulous

    Nearby & related entries:

    Alternative searches for cleavage and polyadenylation specificity factor: