What does cerivastatin mean?
Definitions for cerivastatin
cerivas·tatin
This dictionary definitions page includes all the possible meanings, example usage and translations of the word cerivastatin.
Princeton's WordNet
cerivastatin, Baycolnoun
an oral drug (trade name Baycol) to reduce blood cholesterol levels
Wiktionary
cerivastatinnoun
A synthetic statin formerly used to lower cholesterol and prevent cardiovascular disease, later withdrawn due to the risk of rhabdomyolysis.
Wikipedia
Cerivastatin
Cerivastatin (INN, brand names: Baycol, Lipobay) is a synthetic member of the class of statins used to lower cholesterol and prevent cardiovascular disease. It was marketed by the pharmaceutical company Bayer A.G. in the late 1990s, competing with Pfizer's highly successful atorvastatin (Lipitor). Cerivastatin was voluntarily withdrawn from the market worldwide in 2001, due to reports of fatal rhabdomyolysis. During postmarketing surveillance, 52 deaths were reported in patients using cerivastatin, mainly from rhabdomyolysis and its resultant kidney failure. Risks were higher in patients using fibrates, mainly gemfibrozil (Lopid), and in patients using the highest (0.8 mg/day) dose of cerivastatin. Bayer A.G. added a contraindication for the concomitant use of cerivastatin and gemfibrozil to the package 18 months after the drug interaction was found. The frequency of deadly cases of rhabdomyolysis with cerivastatin was 16 to 80 times higher than with other statins. Another 385 nonfatal cases of rhabdomyolysis were reported. This put the risk of this (rare) complication at 5-10 times that of the other statins. Cerivastatin also induced myopathy in a dose-dependent manner when administered as monotherapy, but that was revealed only after Bayer was sued and unpublished company documents were opened.
ChatGPT
cerivastatin
Cerivastatin is a synthetic lipid-lowering agent and a member of the statin class of drugs, used to help lower cholesterol and prevent cardiovascular disease. It works by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver. However, cerivastatin was withdrawn from the market in 2001 due to its association with fatal rhabdomyolysis, a severe muscle wasting condition.
Wikidata
Cerivastatin
Cerivastatin is a synthetic member of the class of statins used to lower cholesterol and prevent cardiovascular disease. It was marketed by the pharmaceutical company Bayer A.G. in the late 1990s, competing with Pfizer's highly successful atorvastatin. Cerivastatin was voluntarily withdrawn from the market worldwide in 2001, due to reports of fatal rhabdomyolysis. During post-marketing surveillance, 52 deaths were reported in patients using cerivastatin, mainly from rhabdomyolysis and its resultant renal failure. Risks were higher in patients using fibrates, mainly gemfibrozil, and in patients using the highest dose of cerivastatin. Bayer A.G. added a contraindication for the concomitant use of cerivastatin and gemfibrozil to the package 18 months after the drug interaction was found. The frequency of deadly cases of rhabdomyolysis with cerivastatin was 16 to 80 times higher than with other statins. Another 385 nonfatal cases of rhabdomyolysis were reported. This put the risk of this complication at 5-10 times that of the other statins. Cerivastatin also induced myopathy in a dose-dependent manner when administered as monotherapy, but that was revealed only after Bayer was sued and unpublished company documents were opened.
Matched Categories
Numerology
Chaldean Numerology
The numerical value of cerivastatin in Chaldean Numerology is: 9
Pythagorean Numerology
The numerical value of cerivastatin in Pythagorean Numerology is: 6
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"cerivastatin." Definitions.net. STANDS4 LLC, 2024. Web. 23 Apr. 2024. <https://www.definitions.net/definition/cerivastatin>.
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