Definitions for cathelicidin
cathe·li·cidin

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1. cathelicidinnoun

   Any of a family of antimicrobial polypeptides found in lysosomes in polymorphonuclear leukocytes.

WikipediaRate this definition:0.0 / 0 votes

1. Cathelicidin

   Cathelicidin antimicrobial peptide (CAMP) is a polypeptide that is primarily stored in the lysosomes of macrophages and polymorphonuclear leukocytes (PMNs); in humans, the CAMP gene encodes the peptide precursor CAP-18 (18 kDa), which is processed by proteinase 3-mediated extracellular cleavage into the active form LL-37. LL-37 is the only peptide in the Cathelicidin family found in the human body.Cathelicidin peptides are dual-natured molecules called amphiphiles: one end of the molecule is attracted to water and repelled by fats and proteins, and the other end is attracted to fat and proteins and repelled by water. Members of this family react to pathogens by disintegrating, damaging, or puncturing cell membranes. Cathelicidins thus serve a critical role in mammalian innate immune defense against invasive bacterial infection. The cathelicidin family of peptides are classified as antimicrobial peptides (AMPs). The AMP family also includes the defensins. Whilst the defensins share common structural features, cathelicidin-related peptides are highly heterogeneous. Members of the cathelicidin family of antimicrobial polypeptides are characterized by a highly conserved region (cathelin domain) and a highly variable cathelicidin peptide domain.Cathelicidin peptides have been isolated from many different species of mammals. Cathelicidins are mostly found in neutrophils, monocytes, mast cells, dendritic cells and macrophages after activation by bacteria, viruses, fungi, parasites or the hormone 1,25-D, which is the hormonally active form of vitamin D. They have been found in some other cells, including epithelial cells and human keratinocytes.

WikidataRate this definition:0.0 / 0 votes

1. Cathelicidin

   Cathelicidin-related antimicrobial peptides are a family of polypeptides found in lysosomes of macrophages and polymorphonuclear leukocytes. Cathelicidins serve a critical role in mammalian innate immune defense against invasive bacterial infection. Members of the cathelicidin family of antimicrobial polypeptides are characterized by a highly conserved region and a highly variable cathelicidin peptide domain. Cathelicidin peptides have been isolated from many different species of mammals. Cathelicidins were originally found in neutrophils but have since been found in many other cells including epithelial cells and macrophages after activation by bacteria, viruses, fungi, or the hormone 1,25-D, which is the hormonally active form of vitamin D. The cathelicidin family shares primary sequence homology with the cystatin family of cysteine proteinase inhibitors, although amino acid residues thought to be important in such protease inhibition are usually lacking.

How to pronounce cathelicidin?

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Numerology

1. Chaldean Numerology

   The numerical value of cathelicidin in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of cathelicidin in Pythagorean Numerology is: 7

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Cathelicidin
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Cathelicidin
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=cathelicidin