Definitions for caryophyllene
ca·ryophyl·lene

WiktionaryRate this definition:0.0 / 0 votes

1. caryophyllenenoun

   A sesquiterpene (containing a cyclobutane ring) found in the essential oils of several plants such as clove and pepper

WikipediaRate this definition:0.0 / 0 votes

1. Caryophyllene

   Caryophyllene (), more formally (−)-β-caryophyllene, (BCP), is a natural bicyclic sesquiterpene that is a constituent of many essential oils, especially clove oil, the oil from the stems and flowers of Syzygium aromaticum (cloves), the essential oil of Cannabis sativa, rosemary, and hops. It is usually found as a mixture with isocaryophyllene (the cis double bond isomer) and α-humulene (obsolete name: α-caryophyllene), a ring-opened isomer. Caryophyllene is notable for having a cyclobutane ring, as well as a trans-double bond in a 9-membered ring, both rarities in nature. β-Caryophyllene acts as a full agonist of the Cannabinoid receptor type 2 (CB2 receptor) in rats. β-Caryophyllene has a binding affinity of Ki = 155nM at the CB2 receptors in mice. β-Caryophyllene has been shown to have anti-inflammatory action linked to its CB2 receptor activity in a study comparing the pain killing effects in mice with and without CB2 receptors with the group of mice without CB2 receptors seeing little benefit compared to the mice with functional CB2 receptors. β-Caryophyllene has the highest cannabinoid activity compared to the ring opened isomer α-caryophyllene which may modulate CB2 activity. To compare binding, Cannabinol (CBN) binds to the CB2 receptors as a partial agonist with an affinity of CB2 Ki = 126.4 nM while Delta-9-Tetrahydrocannabinol binds to the CB2 receptors as a partial agonist with an affinity of Ki = 36nM.The first total synthesis of caryophyllene in 1964 by E. J. Corey was considered one of the classic demonstrations of the possibilities of synthetic organic chemistry at the time.Caryophyllene is one of the chemical compounds that contributes to the aroma of black pepper.Caryophyllene has been given GRAS (generally regarded as safe) designation by the FDA and is approved by the FDA for use as a food additive, typically for flavoring.Caryophyllene helps to improve cold tolerance at low ambient temperatures. Wild giant pandas frequently roll in horse manure, which contains beta-caryophyllene/caryophyllene oxide, to inhibit transient receptor potential melastatin 8 (TRPM8), an archetypical cold-activated ion channel of mammals.

WikidataRate this definition:0.0 / 0 votes

1. Caryophyllene

   Caryophyllene, or-β-caryophyllene, is a natural bicyclic sesquiterpene that is a constituent of many essential oils, especially clove oil, the oil from the stems and flowers of Syzygium aromaticum, the essential oil of hemp Cannabis sativa, rosemary Rosmarinus oficinalis, and hops. It is usually found as a mixture with isocaryophyllene and α-humulene, a ring-opened isomer. Caryophyllene is notable for having a cyclobutane ring, a rarity in nature. Caryophyllene is one of the chemical compounds that contributes to the spiciness of black pepper. In a study conducted by Jürg Gertsch et al. from the Swiss Federal Institute of Technology, beta-caryophyllene was shown to selectively bind to the cannabinoid receptor type-2 and to exert significant cannabimimetic antiinflammatory effects in mice. Since the widespread plant natural product beta-caryophyllene is an FDA approved food additive and ingested daily with food it is the first dietary cannabinoid. Whether this compound is able to modulate inflammatory processes in humans via the endocannabinoid system is yet unknown. Beta-caryophyllene does not bind to the centrally expressed cannabinoid receptor type-1 and therefore does not exert psychomimetic effects.

How to pronounce caryophyllene?

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Numerology

1. Chaldean Numerology

   The numerical value of caryophyllene in Chaldean Numerology is: 4

2. Pythagorean Numerology

   The numerical value of caryophyllene in Pythagorean Numerology is: 6

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Caryophyllene
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Caryophyllene
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=caryophyllene