Definitions for buruli ulcer
bu·ruli ul·cer

WikipediaRate this definition:0.0 / 0 votes

1. Buruli ulcer

   Buruli ulcer () is an infectious disease characterized by the development of painless open wounds. The disease is limited to certain areas of the world, most cases occurring in Sub-Saharan Africa and Australia. The first sign of infection is a small painless nodule or area of swelling, typically on the arms or legs. The nodule grows larger over days to weeks, eventually forming an open ulcer. Deep ulcers can cause scarring of muscles and tendons, resulting in permanent disability. Buruli ulcer is caused by skin infection with bacteria called Mycobacterium ulcerans. The mechanism by which M. ulcerans is transmitted from the environment to humans is not known, but may involve the bite of an aquatic insect or the infection of open wounds. Once in the skin, M. ulcerans grows and releases the toxin mycolactone, which blocks the normal function of cells, resulting in tissue death and immune suppression at the site of the ulcer. The World Health Organization (WHO) recommends treating Buruli ulcer with a combination of the antibiotics rifampicin and clarithromycin. With antibiotic administration and proper wound care, small ulcers typically heal within six months. Deep ulcers and those on sensitive body sites may require surgery to remove dead tissue or repair scarred muscles or joints. Even with proper treatment, Buruli ulcer can take months to heal. Regular cleaning and dressing of wounds aids healing and prevents secondary infections. In 2018, WHO received 2,713 reports of Buruli ulcer globally. Although rare, it typically occurs in rural areas near slow-moving or stagnant water. The first written description of the disease is credited to Albert Ruskin Cook in 1897 at Mengo Hospital in Uganda. Fifty years later, the causative bacterium was isolated and identified by a group at the Alfred Hospital in Melbourne. In 1998, WHO established the Global Buruli Ulcer Initiative to coordinate global efforts to eliminate Buruli ulcer. WHO considers it a neglected tropical disease.

WikidataRate this definition:0.0 / 0 votes

1. Buruli ulcer

   The Buruli ulcer is an infectious disease caused by Mycobacterium ulcerans. The genus also includes the causative agents of tuberculosis and leprosy. The early stage of infection is characterised by a painless nodule, with non-pyogenic, necrotising lesions developing in the skin, and occasionally in adjacent bone, as the disease progresses. M. ulcerans secretes a lipid toxin, mycolactone, which functions as an immune suppressant, necrotising agent and activator of cellular apoptosis in mammalian tissues.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Buruli Ulcer

   A lesion in the skin and subcutaneous tissues due to infections by MYCOBACTERIUM ULCERANS. It was first reported in Uganda, Africa.

How to pronounce buruli ulcer?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say buruli ulcer in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of buruli ulcer in Chaldean Numerology is: 3

2. Pythagorean Numerology

   The numerical value of buruli ulcer in Pythagorean Numerology is: 7

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Buruli_Ulcer
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=buruli ulcer