What does blood–brain barrier mean?
Definitions for blood–brain barrier
blood·–brain bar·ri·er
This dictionary definitions page includes all the possible meanings, example usage and translations of the word blood–brain barrier.
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Wikipedia
Blood–brain barrier
The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that prevents solutes in the circulating blood from non-selectively crossing into the extracellular fluid of the central nervous system where neurons reside. The blood–brain barrier is formed by endothelial cells of the capillary wall, astrocyte end-feet ensheathing the capillary, and pericytes embedded in the capillary basement membrane. This system allows the passage of some small molecules by passive diffusion, as well as the selective and active transport of various nutrients, ions, organic anions, and macromolecules such as glucose and amino acids that are crucial to neural function.The blood–brain barrier restricts the passage of pathogens, the diffusion of solutes in the blood, and large or hydrophilic molecules into the cerebrospinal fluid, while allowing the diffusion of hydrophobic molecules (O2, CO2, hormones) and small non-polar molecules. Cells of the barrier actively transport metabolic products such as glucose across the barrier using specific transport proteins. The barrier also restricts the passage of peripheral immune factors, like signaling molecules, antibodies, and immune cells, into the CNS, thus insulating the brain from damage due to peripheral immune events.Specialized brain structures participating in sensory and secretory integration within brain neural circuits—the circumventricular organs and choroid plexus—have in contrast highly permeable capillaries.
Wikidata
Blood–brain barrier
The blood–brain barrier is a separation of circulating blood from the brain extracellular fluid in the central nervous system. It occurs along all capillaries and consists of tight junctions around the capillaries that do not exist in normal circulation. Endothelial cells restrict the diffusion of microscopic objects and large or hydrophilic molecules into the cerebrospinal fluid, while allowing the diffusion of small hydrophobic molecules. Cells of the barrier actively transport metabolic products such as glucose across the barrier with specific proteins. This barrier also includes a thick basement membrane and astrocytic endfeet.
Numerology
Chaldean Numerology
The numerical value of blood–brain barrier in Chaldean Numerology is: 4
Pythagorean Numerology
The numerical value of blood–brain barrier in Pythagorean Numerology is: 1
Examples of blood–brain barrier in a Sentence
Nobody thought that many of the proteins or bio markers that affect the brain would even be in blood. It was thought, basically, that those proteins and those markers would only be in the brain in the spinal fluid, but what we’ve learned is that a small amount of the spinal fluid, the cerebral spinal fluid, actually leaks into the blood through the blood brain barrier and because our technology can detect things that are so minute in blood, we can test what’s going on in the brain.
It was those iconic images of the dead albatross chicks on the Pacific Islands with their stomachs open and all recognizable plastic items inside it, and most recently, it's been when we discovered the nano-particles do cross the blood-brain barrier, and we were able to prove that plastic is in us.
My quotes are like an endless stream in the reality of life. Those who learn from what I share become the ground penetrating, mesmerizing forces, seen but unseen, to which no technology can detect. The forces which traverses the blood brain barrier leaving no visible mark on the M.R.I images.
What's interesting is that the blood-brain barrier is a two-way street, by breaking it down, you can get things into the brain, but also by breaking it down now things can go from your brain out into your circulation, to your peripheral system, which includes your immune system.
The struggle with Sanfilippo is there’s a lot of the cell waste from the disorder in the brain, and the problem with treating it in the past is they can’t get the enzymes past the blood brain barrier. We’re waiting to see if this trial has figured it out.
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"blood–brain barrier." Definitions.net. STANDS4 LLC, 2024. Web. 28 Mar. 2024. <https://www.definitions.net/definition/blood%E2%80%93brain+barrier>.
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