Definitions for bioavailability
ˌbaɪ oʊ əˌveɪ ləˈbɪl ɪ tibioavail·abil·i·ty

WiktionaryRate this definition:0.0 / 0 votes

1. bioavailabilitynoun

   The amount of drug which reaches the site of physiological activity after administration.

WikipediaRate this definition:0.0 / 0 votes

1. Bioavailability

   In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation.By definition, when a medication is administered intravenously, its bioavailability is 100%. However, when a medication is administered via routes other than intravenous, its bioavailability is generally lower than that of intravenous due to intestinal endothelium absorption and first-pass metabolism. Thereby, mathematically, bioavailability equals the ratio of comparing the area under the plasma drug concentration curve versus time (AUC) for the extravascular formulation to the AUC for the intravascular formulation. AUC is used because AUC is proportional to the dose that has entered the systemic circulation.Bioavailability of a drug is an average value; to take population variability into account, deviation range is shown as ±. To ensure that the drug taker who has poor absorption is dosed appropriately, the bottom value of the deviation range is employed to represent real bioavailability and to calculate the drug dose needed for the drug taker to achieve systemic concentrations similar to the intravenous formulation. To dose without knowing the drug taker's absorption rate, the bottom value of the deviation range is used in order to ensure the intended efficacy, unless the drug is associated with a narrow therapeutic window.For dietary supplements, herbs and other nutrients in which the route of administration is nearly always oral, bioavailability generally designates simply the quantity or fraction of the ingested dose that is absorbed.

WikidataRate this definition:0.0 / 0 votes

1. Bioavailability

   In pharmacology, bioavailability is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. By definition, when a medication is administered intravenously, its bioavailability is 100%. However, when a medication is administered via other routes, its bioavailability generally decreases or may vary from patient to patient. Bioavailability is one of the essential tools in pharmacokinetics, as bioavailability must be considered when calculating dosages for non-intravenous routes of administration. For dietary supplements, herbs and other nutrients in which the route of administration is nearly always oral, bioavailability generally designates simply the quantity or fraction of the ingested dose that is absorbed. Bioavailability is defined slightly differently for drugs as opposed to dietary supplements primarily due to the method of administration and Food and Drug Administration regulations. Bioaccessibility is a concept related to bioavailability in the context of biodegradation and environmental pollution. A molecule is said to be bioavailable when "[it] is available to cross an organism’s cellular membrane from the environment, if the organism has access to the chemical."

How to pronounce bioavailability?

1. Alex

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   Australian

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How to say bioavailability in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of bioavailability in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of bioavailability in Pythagorean Numerology is: 5

Examples of bioavailability in a Sentence

1. Melissa Rifkin:

   If you pair the turmeric with the piperine, it improves the bioavailability of curcumin by 1000 times.

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Bioavailability
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Bioavailability
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=bioavailability