B-cell CLL/lymphoma 2
Bcl-2, encoded by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death. Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Bcl-2 orthologs have been identified in numerous mammals for which complete genome data are available. The two isoforms of Bcl-2, Isoform 1, also known as 1G5M, and Isoform 2, also known as 1G5O/1GJH, exhibit similar fold. However, results in the ability of these isoforms to bind to the BAD and BAK proteins, as well as in the structural topology and electrostatic potential of the binding groove, suggest differences in antiapoptotic activity for the two isoforms
The numerical value of b-cell cll/lymphoma 2 in Chaldean Numerology is: 4
The numerical value of b-cell cll/lymphoma 2 in Pythagorean Numerology is: 2
Images & Illustrations of b-cell cll/lymphoma 2
Find a translation for the b-cell cll/lymphoma 2 definition in other languages:
Select another language:
Discuss these b-cell cll/lymphoma 2 definitions with the community:
Word of the Day
Would you like us to send you a FREE new word definition delivered to your inbox daily?
Use the citation below to add this definition to your bibliography:
"b-cell cll/lymphoma 2." Definitions.net. STANDS4 LLC, 2018. Web. 21 Nov. 2018. <https://www.definitions.net/definition/b-cell+cll%2Flymphoma+2>.