Definitions for atropisomer
at·ropi·so·mer

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1. atropisomernoun

   any conformer that can be isolated as a separate chemical compound and that arises from restricted rotation about a single bond

WikipediaRate this definition:0.0 / 0 votes

1. Atropisomer

   Atropisomers are stereoisomers arising because of hindered rotation about a single bond, where energy differences due to steric strain or other contributors create a barrier to rotation that is high enough to allow for isolation of individual conformers. They occur naturally and are important in pharmaceutical design. When the substituents are achiral, these conformers are enantiomers (atropoenantiomers), showing axial chirality; otherwise they are diastereomers (atropodiastereomers).

WikidataRate this definition:2.0 / 1 vote

1. Atropisomer

   Atropisomers are stereoisomers resulting from hindered rotation about single bonds where the steric strain barrier to rotation is high enough to allow for the isolation of the conformers. The word atropisomer is derived from the Greek a, meaning not, and tropos, meaning turn. The name was coined by Kuhn in 1933, but atropisomerism was first detected in 6,6’-dinitro-2,2’-diphenic acid by Christie in 1922. Oki defined atropisomers as conformers that interconvert with a half-life of more than 1000 seconds at a given temperature. Atropisomers are an important class of compounds because they display axial chirality. They differ from other chiral compounds in that they can be equilibrated thermally whereas in the other forms of chirality isomerization is usually only possible chemically. The most important class of atropisomers are biaryls such as diphenic acid, which is a derivative of biphenyl with a complete set of ortho substituents. Others are dimers of naphthalene derivatives such as 1,1'-bi-2-naphthol. In a similar way, aliphatic ring systems like cyclohexanes linked through a single bond may display atropisomerism provided that bulky substituents are present. Examples of naturally occurring atropisomers include vancomycin isolated from an Actinobacterium and knipholone, which is found in the roots of Kniphofia foliosa of the family Asphodelaceae.

Anagrams for atropisomer »

1. aerotropism

2. aërotropism

How to pronounce atropisomer?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say atropisomer in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of atropisomer in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of atropisomer in Pythagorean Numerology is: 5

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Atropisomer
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Atropisomer
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=atropisomer