Definitions for artemisinin
artemisinin

WiktionaryRate this definition:0.0 / 0 votes

1. artemisininnoun

   an anti-malarial drug derived from the wormwood shrub, found as the active ingredient in traditional Chinese medical herbal treatment for malaria, chemically a sesquiterpene lactone

WikipediaRate this definition:0.0 / 0 votes

1. Artemisinin

   Artemisinin () and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to Plasmodium falciparum. It was discovered in 1972 by Tu Youyou, who shared the 2015 Nobel Prize in Physiology or Medicine for her discovery. Artemisinin-based combination therapies (ACTs) are now standard treatment worldwide for P. falciparum malaria as well as malaria due to other species of Plasmodium. Artemisinin is extracted from the plant Artemisia annua, sweet wormwood, a herb employed in Chinese traditional medicine. A precursor compound can be produced using a genetically engineered yeast, which is much more efficient than using the plant.Artemisinin and its derivatives are all sesquiterpene lactones containing an unusual peroxide bridge. This endoperoxide 1,2,4-trioxane ring is responsible for their antimalarial properties. Few other natural compounds with such a peroxide bridge are known.Artemisinin and its derivatives have been used for the treatment of malarial and parasitic worm (helminth) infections. They have the advantage over other drugs in having an ability to kill faster and kill all the life cycle stages of the parasites. But low bioavailability, poor pharmacokinetic properties and high cost of the drugs are major drawbacks of their use. Use of the drug by itself as a monotherapy is explicitly discouraged by the World Health Organization, as there have been signs that malarial parasites are developing resistance to the drug. Therapies that combine artemisinin or its derivatives with some other antimalarial drug are the preferred treatment for malaria.

WikidataRate this definition:0.0 / 0 votes

1. Artemisinin

   Artemisinin, also known as Qinghaosu, and its derivatives are a group of drugs that possess the most rapid action of all current drugs against Plasmodium falciparum malaria. Treatments containing an artemisinin derivative are now standard treatment worldwide for P. falciparum malaria. The starting compound artemisinin is isolated from the plant Artemisia annua, sweet wormwood, a herb employed in Chinese traditional medicine. Chemically, artemisinin is a sesquiterpene lactone containing an unusual peroxide bridge. This peroxide is believed to be responsible for the drug's mechanism of action. Few other natural compounds with such a peroxide bridge are known. Use of the drug by itself as a monotherapy is explicitly discouraged by the World Health Organization, as there have been signs that malarial parasites are developing resistance to the drug. Therapies that combine artemisinin with some other antimalarial drug are the preferred treatment for malaria and are both effective and well tolerated in patients. The drug is also increasingly being used in Plasmodium vivax malaria, as well as being a topic of research in cancer treatment.

How to pronounce artemisinin?

1. Alex

   US English

   David

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   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

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   Tessa

   South African

How to say artemisinin in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of artemisinin in Chaldean Numerology is: 5

2. Pythagorean Numerology

   The numerical value of artemisinin in Pythagorean Numerology is: 5

Examples of artemisinin in a Sentence

1. Philippe Guerin:

   The pace at which artemisinin resistance is spreading or emerging is alarming.

2. Elizabeth Sattely:

   Producing plant-derived drugs in easy-to-grow plants or baker's yeast in many cases will be a much more efficient way to make these drugs, this is currently being done for artemisinin (a malaria drug derived from the sweet wormwood plant), and will likely be the way we make morphine (derived from poppies) in the future.

3. Patricia Moser:

   We support the bold push towards elimination as it has become clear that containment of artemisinin resistance is a risky strategy - the region must push for elimination while these key drugs (artemisinin combination therapies) remain effective.

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Artemisinin
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Artemisinin
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=artemisinin