What does anaphase-promoting complex mean?
Definitions for anaphase-promoting complex
anaphase-pro·mot·ing com·plex
This dictionary definitions page includes all the possible meanings, example usage and translations of the word anaphase-promoting complex.
Wiktionary
anaphase-promoting complexnoun
A complex of several proteins which is activated during mitosis to initiate anaphase
Wikipedia
Anaphase-promoting complex
Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF. Other parts of the APC/C have unknown functions but are highly conserved.It was the discovery of the APC/C (and SCF) and their key role in eukaryotic cell-cycle regulation that established the importance of ubiquitin-mediated proteolysis in cell biology. Once perceived as a system exclusively involved in removing damaged protein from the cell, ubiquitination and subsequent protein degradation by the proteasome is now perceived as a universal regulatory mechanism for signal transduction whose importance approaches that of protein phosphorylation. In 2014, the APC/C was mapped in 3D at a resolution of less than a nanometre, which also uncovered its secondary structure. This finding could improve understanding of cancer and reveal new binding sites for future cancer drugs.
Wikidata
Anaphase-promoting complex
Anaphase-Promoting Complex, also called cyclosome, is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin and RING subunit much like SCF. Other parts of the APC/C still have unknown functions, but are highly conserved. It was the discovery of the APC/C and the key role that they have in eukaryotic cell reproduction that established once and for all the importance of ubiquitin-mediated proteolysis in eukaryotic cell biology. Once perceived as a system exclusively involved in removing damaged protein from the cell, ubiquitination and subsequent protein degradation by the proteasome is now perceived as a universal regulatory mechanism for signal transduction whose importance approaches that of protein phosphorylation.
Numerology
Chaldean Numerology
The numerical value of anaphase-promoting complex in Chaldean Numerology is: 6
Pythagorean Numerology
The numerical value of anaphase-promoting complex in Pythagorean Numerology is: 1
Translations for anaphase-promoting complex
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- 後期促進複合物Chinese
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