Definitions for amyloid plaques
amy·loid plaques

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1. Amyloid plaques

   Amyloid plaques (also known as neuritic plaques, amyloid beta plaques or senile plaques) are extracellular deposits of the amyloid beta (Aβ) protein mainly in the grey matter of the brain. Degenerative neuronal elements and an abundance of microglia and astrocytes can be associated with amyloid plaques. Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. Abnormal neurites in amyloid plaques are tortuous, often swollen axons and dendrites. The neurites contain a variety of organelles and cellular debris, and many of them include characteristic paired helical filaments, the ultrastructural component of neurofibrillary tangles. The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve with an average plaque area of 400-450 square micrometers (µm²). The smallest plaques (less than 200 µm²), which often consist of diffuse deposits of Aβ, are particularly numerous. The apparent size of plaques is influenced by the type of stain used to detect them, and by the plane through which they are sectioned for analysis under the microscope. Plaques form when Aβ misfolds and aggregates into oligomers and longer polymers, the latter of which are characteristic of amyloid. Misfolded and aggregated Aβ is thought to be neurotoxic, especially in its oligomeric state.

How to pronounce amyloid plaques?

1. Alex

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   Mark

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   Daniel

   British

   Libby

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   Mia

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   Australian

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How to say amyloid plaques in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of amyloid plaques in Chaldean Numerology is: 3

2. Pythagorean Numerology

   The numerical value of amyloid plaques in Pythagorean Numerology is: 8

Examples of amyloid plaques in a Sentence

1. Stephen Salloway:

   Marc actually tried out for aducanumab [trials] twice but he flunked because he did too well on his memory tests, we knew he had Alzheimer’s and he was building up amyloid plaques in the brain and had an increased genetic risk for Alzheimer’s.

2. Patrizia Cavazzoni:

   In all studies in which it was evaluated, however, Aduhelm consistently and very convincingly reduced the level of amyloid plaques in the brain in a dose - and time-dependent fashion, it is expected that the reduction in amyloid plaque will result in a reduction in clinical decline.

3. Aaron Kesselheim:

   The FDA is totally switching gears over the last six months and approving this drug on the basis of a theory relating to the surrogate marker of amyloid plaques that we, as an advisory committee back in November, were told to not consider, if The FDA allows companies to get drugs approved on the basis of trials that are stopped early, trials that are reanalyzed, that sets a precedent.

4. Marc Flajolet:

   Most studies carried out till now were targeting the very late steps of this whole multi-step process, and we thought, ‘Let’s look at the very early steps and maybe we’ll have more chances to modulate this pathway,’ we found that was not only the case for amyloid plaques, but that it also worked in this animal model for memory.

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Amyloid_Plaques