Definitions for amantadine
əˈmæn təˌdinaman·ta·dine

WiktionaryRate this definition:0.0 / 0 votes

1. amantadinenoun

   A polycyclic amine, 1-aminoadamantane, that is an antiviral drug used in the treatment of Parkinson's disease

WikipediaRate this definition:0.0 / 0 votes

1. Amantadine

   Amantadine, sold under the brand name Gocovri among others, is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type A influenzavirus, though its use for the latter is no longer recommended due to widespread drug resistance. It acts as a nicotinic antagonist, dopamine agonist, and noncompetitive NMDA antagonist. The antiviral mechanism of action is antagonism of the influenzavirus A M2 proton channel, which prevents endosomal escape (i.e. the release of viral genetic material into the host cytoplasm).Amantadine was first used for the treatment of influenza A. After antiviral properties were initially reported in 1963, amantadine received approval for prophylaxis against the influenza virus A in 1976. In 1973, the Food and Drug Administration (FDA) approved amantadine for use in the treatment of Parkinson's disease. In 2017, the extended release formulation was approved for use in the treatment of levodopa-induced dyskinesia. Amantadine has a mild side effect profile. Common neurological side effects include drowsiness, light headedness, dizziness, and confusion. Due to its effects on the central nervous system, it should not be combined with additional CNS stimulants or anticholinergic drugs. Amantadine is contraindicated in persons with end stage kidney disease, given that the drug is cleared by the kidneys. It should also be taken with caution in those with enlarged prostates or glaucoma, due to its anticholinergic effects.

WikidataRate this definition:0.0 / 0 votes

1. Amantadine

   Amantadine is a drug that has US Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. It is the organic compound 1-adamantylamine or 1-aminoadamantane, meaning it consists of an adamantane backbone that has an amino group substituted at one of the four methyne positions. Rimantadine is a closely related derivative of adamantane with similar biological properties. Apart from medical uses, this compound is useful as a building block, allowing the insertion of an adamantyl group. According to the US Centers for Disease Control and Prevention, 100% of seasonal H3N2 and 2009 pandemic flu samples tested have shown resistance to adamantanes, and amantadine is no longer recommended for treatment of influenza in the United States. Additionally, its effectiveness as an antiparkinsonian drug is undetermined, with a 2003 Cochrane Review concluding that there was insufficient evidence in support or against its efficacy and safety.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Amantadine

   An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

Anagrams for amantadine »

1. adamantine

2. diamantane

How to pronounce amantadine?

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Numerology

1. Chaldean Numerology

   The numerical value of amantadine in Chaldean Numerology is: 4

2. Pythagorean Numerology

   The numerical value of amantadine in Pythagorean Numerology is: 1

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Amantadine
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Amantadine
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=amantadine