What does alpha-synuclein mean?
Definitions for alpha-synuclein
al·pha-synu·cle·in
This dictionary definitions page includes all the possible meanings, example usage and translations of the word alpha-synuclein.
Wikipedia
Alpha-synuclein
Alpha-synuclein (aSyn) is a protein that, in humans, is encoded by the SNCA gene. Alpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter release.It is abundant in the brain, while smaller amounts are found in the heart, muscle and other tissues. In the brain, alpha-synuclein is found mainly in the axon terminals of presynaptic neurons. Within these terminals, alpha-synuclein interacts with phospholipids and proteins. Presynaptic terminals release chemical messengers, called neurotransmitters, from compartments known as synaptic vesicles. The release of neurotransmitters relays signals between neurons and is critical for normal brain function.Parkinson disease and others synucleinopathies cause Lewy bodies and Lewy neurites to accumulate as a highly soluble unfolded protein called α-Synuclein.Familial Parkinson disease is associated with mutations in the -synuclein (SNCA) gene. In the process of seeded nucleation, alpha-synuclein acquires a cross-sheet structure similar to other amyloids.The human alpha-synuclein protein is made of 140 amino acids. An alpha-synuclein fragment, known as the non-Abeta component (NAC) of Alzheimer's disease amyloid, originally found in an amyloid-enriched fraction, was shown to be a fragment of its precursor protein, NACP. It was later determined that NACP was the human homologue of Torpedo synuclein. Therefore, NACP is now referred to as human alpha-synuclein.
Wikidata
Alpha-synuclein
Alpha-synuclein is a protein that, in humans, is encoded by the SNCA gene. An alpha-synuclein fragment, known as the non-Abeta component of Alzheimer's disease amyloid, originally found in an amyloid-enriched fraction, was shown to be a fragment of its precursor protein, NACP. It was later determined that NACP was the human homologue of Torpedo synuclein. Therefore, NACP is now referred to as human alpha-synuclein.
U.S. National Library of Medicine
alpha-Synuclein
A synuclein that is a major component of LEWY BODIES that plays a role in neurodegeneration and neuroprotection.
Numerology
Chaldean Numerology
The numerical value of alpha-synuclein in Chaldean Numerology is: 5
Pythagorean Numerology
The numerical value of alpha-synuclein in Pythagorean Numerology is: 7
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"alpha-synuclein." Definitions.net. STANDS4 LLC, 2024. Web. 19 Apr. 2024. <https://www.definitions.net/definition/alpha-synuclein>.
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