Definitions for Thalidomide
θəˈlɪd əˌmaɪdthalido·mide

Princeton's WordNetRate this definition:5.0 / 1 vote

1. thalidomidenoun

   a sedative and hypnotic drug; withdrawn from sale after discovered to cause severe birth defects because it inhibits angiogenesis

WiktionaryRate this definition:0.0 / 0 votes

1. thalidomidenoun

   A drug that was sold during the late 1950s and 1960s as a sleeping aid, and to pregnant women as an antiemetic to combat morning sickness and other symptoms, but was withdrawn after being proven to cause severe birth defects, such as phocomelia; currently used to treat leprosy.

WikipediaRate this definition:0.0 / 0 votes

1. Thalidomide

   Thalidomide, sold under the brand names Contergan and Thalomid among others, is an oral medication used to treat a number of cancers (including multiple myeloma), graft-versus-host disease, and a number of skin conditions including complications of leprosy. While thalidomide has been used in a number of HIV-associated conditions, such use is associated with increased levels of the virus.Common side effects include sleepiness, rash, and dizziness. Severe side effects include tumor lysis syndrome, blood clots, and peripheral neuropathy. Use in pregnancy may harm the fetus, including resulting in malformation of the limbs. In males who are taking the medication, contraception is essential if a partner could become pregnant. It is an immunomodulatory medication and works by a number of mechanisms, including stimulating T cells and decreasing TNF-α production.Thalidomide was first marketed in 1957 in West Germany, where it was available over the counter. When first released, thalidomide was promoted for anxiety, trouble sleeping, "tension", and morning sickness. While it was initially thought to be safe in pregnancy, concerns regarding birth defects arose, resulting in its removal from the market in Europe in 1961. The total number of infants affected by thalidomide use during pregnancy is estimated at 10,000, of whom about 40% died around the time of birth. Those who survived had limb, eye, urinary tract, and heart problems. Its initial entry into the US market was prevented by Frances Kelsey, a reviewer at the FDA. The birth defects caused by thalidomide led to the development of greater drug regulation and monitoring in many countries.It was approved in the United States in 1998 for use as a treatment for cancer. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication.

ChatGPTRate this definition:0.0 / 0 votes

1. thalidomide

   Thalidomide is a synthetic drug that was initially developed in the 1950s as a sedative and later used to alleviate morning sickness in pregnant women. Unfortunately, it caused severe birth defects, including limb defects, when used in early pregnancy. Its disastrous effects led to tighter drug regulations worldwide. Today, thalidomide is used under strict controls to treat diseases like leprosy and multiple myeloma.

WikidataRate this definition:0.0 / 0 votes

1. Thalidomide

   Thalidomide is an anti-nausea and sedative drug that was introduced in the late 1950s to be used as a sleeping pill, and was quickly discovered to help pregnant women with the effects of morning sickness. It was sold from 1957 until 1962, when it was withdrawn after being found to be a teratogen, which caused many different forms of birth defects. The negative effects of thalidomide led to the development of more structured drug regulations and control over drug use and development. Modern uses of thalidomide include treating multiple myeloma in combination with dexamethasone, treating erythema nodosum leprosum, and alleviating symptoms of HIV, with strict controls to prevent birth defects. Research is ongoing in its use to treat other cancers and autoimmune conditions, although its use is controversial.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Thalidomide

   A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.

Matched Categories

1. • Sedative-hypnotic
   • Teratogen

How to pronounce Thalidomide?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say Thalidomide in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of Thalidomide in Chaldean Numerology is: 3

2. Pythagorean Numerology

   The numerical value of Thalidomide in Pythagorean Numerology is: 1

Examples of Thalidomide in a Sentence

1. Frank Schoenrock:

   We deeply regret the thalidomide tragedy and it will always be part of our corporate history.

2. Adriana Scavuzzi:

   It will be worse than the Thalidomide generation because then the cause could be withdrawn from the market, but how do you withdraw from circulation a mosquito that has lived with us for so long?

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References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=Thalidomide
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Thalidomide
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Thalidomide
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=Thalidomide