Definitions for Spinal Muscular Atrophy
spinal mus·cu·lar atro·phy

WikidataRate this definition:0.0 / 0 votes

1. Spinal muscular atrophy

   Spinal muscular atrophy is an autosomal recessive disease caused by a genetic defect in the SMN1 gene that codes SMN, a protein widely expressed in all eukaryotic cells. SMN1 is apparently selectively necessary for survival of motor neurons, as diminished abundance of the protein results in death of neuronal cells in the anterior horn of the spinal cord and subsequent system-wide muscle wasting. Spinal muscular atrophy manifests in various degrees of severity which all have in common general muscle wasting and mobility impairment. Other body systems may be affected as well, particularly in early-onset forms. SMA is the most common genetic cause of infant death. The term spinal muscular atrophy is used as both a specific term for the genetic disorder caused by deficient SMN, and a general label for a larger number of rare disorders having in common a genetic cause and slow progression of weakness without sensory impairment caused by disease of motor neurons in the spinal cord and brainstem – see spinal muscular atrophies for a comparison chart.

How to pronounce Spinal Muscular Atrophy?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say Spinal Muscular Atrophy in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of Spinal Muscular Atrophy in Chaldean Numerology is: 5

2. Pythagorean Numerology

   The numerical value of Spinal Muscular Atrophy in Pythagorean Numerology is: 3

Examples of Spinal Muscular Atrophy in a Sentence

1. Chief Executive George Scangos:

   I hope we can transform the treatment of MS. By that time, we will have made substantial progress on ALS and other nerve degenerative diseases, spinal muscular atrophy in kids. All that stuff is on our plate.

2. Chief Executive George Scangos:

   Five years down the road, with some luck, we'll have an Alzheimer's drug that's getting approved, i hope we can transform the treatment of MS. By that time, we will have made substantial progress on ALS and other nerve degenerative diseases, spinal muscular atrophy in kids. All that stuff is on our plate.

3. Laura Van Doormaal:

   When we first took her home, we were in newborn bliss. Just absolutely in love with her. She was a great baby, but we started to realize her movement was declining. She had trouble breathing and eating. When she was five weeks old, she was diagnosed with spinal muscular atrophy.

References

1. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=Spinal Muscular Atrophy