What does Machado–Joseph disease mean?
Definitions for Machado–Joseph disease
machado–joseph dis·ease
This dictionary definitions page includes all the possible meanings, example usage and translations of the word Machado–Joseph disease.
Wikidata
Machado–Joseph disease
'Machado–Joseph disease' or Spinocerebellar ataxia type 3 is a rare autosomal, dominantly inherited neurodegenerative disease that causes progressive cerebellar ataxia, which results in a lack of muscle control and coordination of the upper and lower extremities. The symptoms are caused by a genetic mutation that results in an expansion of abnormal "CAG" trinucleotide repeats in the ATXN3 gene that results in an abnormal form of the protein ataxin which causes degeneration of cells in the hindbrain. Some symptoms, such as clumsiness and rigidity, make MJD commonly mistaken for drunkenness and/or Parkinson's disease. Machado–Joseph disease is a type of spinocerebellar ataxia and is the most common cause of autosomal-dominant ataxia. MJD causes ophthalmoplegia and mixed sensory and cerebellar ataxia.
Numerology
Chaldean Numerology
The numerical value of Machado–Joseph disease in Chaldean Numerology is: 4
Pythagorean Numerology
The numerical value of Machado–Joseph disease in Pythagorean Numerology is: 9
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"Machado–Joseph disease." Definitions.net. STANDS4 LLC, 2024. Web. 24 Apr. 2024. <https://www.definitions.net/definition/Machado%E2%80%93Joseph+disease>.
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