Definitions for IC50
ic50

WiktionaryRate this definition:5.0 / 1 vote

1. IC50abbreviation

   The concentration of an inhibitor that is required for 50-percent inhibition of an enzyme in vitro.

WikipediaRate this definition:0.0 / 0 votes

1. IC50

   The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, in vitro, a given biological process or biological component by 50%. The biological component could be an enzyme, cell, cell receptor or microorganism. IC50 values are typically expressed as molar concentration. IC50 is commonly used as a measure of antagonist drug potency in pharmacological research. IC50 is comparable to other measures of potency, such as EC50 for excitatory drugs. EC50 represents the dose or plasma concentration required for obtaining 50% of a maximum effect in vivo.IC50 can be determined with functional assays or with competition binding assays. Sometimes, IC50 values are converted to the pIC50 scale. pIC 50 = − log 10 ⁡ ( IC 50 ) {\displaystyle {\ce {pIC_{50}}}=-\log _{10}{\ce {(IC_{50})}}} Due to the minus sign, higher values of pIC50 indicate exponentially more potent inhibitors. pIC50 is usually given in terms of molar concentration (mol/L, or M), thus requiring IC50 in units of M.The IC50 terminology is also used for some behavioral measures in vivo, such as a two bottle fluid consumption test. When animals decrease consumption from the drug-laced water bottle, the concentration of the drug that results in a 50% decrease in consumption is considered the IC50 for fluid consumption of that drug.

WikidataRate this definition:4.3 / 4 votes

1. IC50

   The half maximal inhibitory concentration is a measure of the effectiveness of a compound in inhibiting biological or biochemical function. This quantitative measure indicates how much of a particular drug or other substance is needed to inhibit a given biological process by half. In other words, it is the half maximal inhibitory concentration of a substance. It is commonly used as a measure of antagonist drug potency in pharmacological research. According to the FDA, IC50 represents the concentration of a drug that is required for 50% inhibition in vitro. It is comparable to an EC50 for agonist drugs. EC50 also represents the plasma concentration required for obtaining 50% of a maximum effect in vivo.

Editors ContributionRate this definition:3.7 / 3 votes

1. IC50

   IC 50 is the dose of the drug required to kill 50%of cancer cells.The smaller the IC 50, more potent the drug is. Drugs having large IC50 can be toxic and can have side effects.

   IC50 is given to patients only in critical conditions.

   
   

   Submitted by anonymous on March 15, 2019  

How to pronounce IC50?

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Numerology

1. Chaldean Numerology

   The numerical value of IC50 in Chaldean Numerology is: 4

2. Pythagorean Numerology

   The numerical value of IC50 in Pythagorean Numerology is: 3

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Ic50
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Ic50
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=IC50