Tours

The capital of the Indre-et-Loire du00E9partement, in Centre, in France

— Wiktionary

Rhone-Alpes

a mountainous region of eastern France drained by the Rhone and Saone and Isere rivers

— Princeton's WordNet

Angers

A city in Pays de la Loire, France

— Wiktionary

bucheron

A goat's milk cheese from the Loire Valley in France.

— Wiktionary

Et cetera

alt. of Et caetera

— Webster Dictionary

Anjou

a former province of western France in the Loire valley

— Princeton's WordNet

Chenin blanc

made in California and the Loire valley in France

— Princeton's WordNet

Vingtun

contraction for Vingt et un

— Webster Dictionary

Sarthe

one of the departments in Pays de la Loire, France (INSEE number 72).

— Wiktionary

Nantes

a port city in western France on the Loire estuary

— Princeton's WordNet

Muscadet

dry white wine from the Loire valley in France

— Princeton's WordNet

Muscadet

white grape grown especially in the valley the Loire in France

— Princeton's WordNet

Mayenne

a department of northwestern France in the Pays de la Loire region

— Princeton's WordNet

Chenin blanc

white grape grown especially in California and the lower Loire valley of France

— Princeton's WordNet

Vouvray

a dry white French wine (either still or sparkling) made in the Loire valley

— Princeton's WordNet

Vendu00E9e

One of the du00E9partements of Pays de la Loire, France.

— Wiktionary

vingtun

The card game vingt-et-un.

— Wiktionary

Mayenne

One of the du00E9partements of Pays de la Loire, France (number 53)

— Wiktionary

spazmo

A stupid person; moron, imbecile, fool, et cetera.

— Wiktionary

cooperation

Active help from a person, organization, et cetera.

— Wiktionary

Saumur

a town of France, in the department of Maine-et-Loire, situated on the Loire and partly on an island in the river, 32 m. SE. of Angers; once famous for its Protestant theological seminary, and till the Edict of Nantes a stronghold of the Huguenots; has interesting churches, a castle (still used as an arsenal), and a noted cavalry school; has trade in grain, dried fruits, rosaries, &c.

— The Nuttall Encyclopedia

Orleans

a city on the Loire river in north central France; site of the siege of Orleans by the English (1428-1429)

— Princeton's WordNet

Chomskyan

Following the theoretical approach introduced by Noam Chomsky, et al.

— Wiktionary

Langue d'oil

the dialect formerly spoken north of the Loire (in which the word for "yes" was oil, F. oui)

— Webster Dictionary

etc.

et cetera; used at the end of a list to mean "all other similar things"

— Kernerman English Learner's Dictionary

epicure

A person with highly refined tastes in food, wine, music et cetera.

— Wiktionary

induct

to formally or ceremoniously install in an office, position, et cetera.

— Wiktionary

Langue d'oc

the dialect, closely akin to French, formerly spoken south of the Loire (in which the word for "yes" was oc); Provencal

— Webster Dictionary

Creusot, Le

a town in the dep. Saône-et-Loire, near Autun, which owes its importance to the large iron-works established there; is a district rich in coal and iron.

— The Nuttall Encyclopedia

in dictione

Deriving from the linguistic expression used; for reason of ambiguity, division, et cetera.

— Wiktionary

muscadet

A white grape grown chiefly in the Loire valley of France, or a dry white wine made from this grape

— Wiktionary

ah

An expression of relief, relaxation, comfort, confusion, understanding, wonder, awe, et cetera according to uttered inflection.

— Wiktionary

extra dictionem

Not deriving from the linguistic expression used; for a reason other than of ambiguity, division, et cetera.

— Wiktionary

Autun`

an ancient city in the dep. of Saône-et-Loire, on the Arroux, 28 m. NW. from Châlons, where Talleyrand was bishop, with a fine cathedral and rich in antiquities; manufactures serges, carpets, velvet, &c.

— The Nuttall Encyclopedia

collate

To examine diverse documents et cetera to discover similarities and differences.

— Wiktionary

Trespass

an unlawful act committed with force and violence (vi et armis) on the person, property, or relative rights of another

— Webster Dictionary

dominus vobiscum

A devout salutation often used as a prelude to certain set prayers; the traditional response is Et cum spiritu tuo.

— Wiktionary

Chambord

spacious château in the dep. of Loire-et-Cher, France, built by Francis I.; after being long a residence for royalty and people of distinction, was presented in 1821 to the Duc de Bordeaux, the Comte de Chambord.

— The Nuttall Encyclopedia

Ureide

any one of the many complex derivatives of urea; thus, hydantoin, and, in an extended dense, guanidine, caffeine, et., are ureides

— Webster Dictionary

Department

a territorial division; a district; esp., in France, one of the districts composed of several arrondissements into which the country is divided for governmental purposes; as, the Department of the Loire

— Webster Dictionary

Ai

a Canaanite royal city mentioned in the Book of Joshua, popularly believed to be the modern archeological site Et-Tell.

— Wiktionary

Cardinal Nephew

The position of the Secretarius Papae et superintendens status ecclesiasticu00E6 in the sixteenth- and seventeenth-century Holy See.

— Wiktionary

research

Diligent inquiry or examination to seek or revise facts, principles, theories, applications, et cetera; laborious or continued search after truth.

— Wiktionary

agricultural

Of or pertaining to agriculture; connected with, or engaged in, tillage; as, the agricultural class; agricultural implements, wages, et cetera.

— Wiktionary

Roanne

an old French town in the department of Loire, on the river Loire, 49 m. NW of St. Étienne; has interesting ruins, a college flourishing cotton and hat factories, dye-works, tanneries, &c.

— The Nuttall Encyclopedia

all that

That, and everything similar; all of that kind of thing; and so on, et cetera.

— Wiktionary

Syllepsis

the agreement of a verb or adjective with one, rather than another, of two nouns, with either of which it might agree in gender, number, etc.; as, rex et regina beati

— Webster Dictionary

Divorce

the separation of a married woman from the bed and board of her husband -- divorce a mensa et toro (/ thoro), "from bed board."

— Webster Dictionary

Curbstone

a stone /et along a margin as a and protection, as along the edge of a sidewalk next the roadway; an edge stone

— Webster Dictionary

Blois

capital of the deps. of Loire and Cher, France, on the Loire, 35 m. S. of Orleans; a favourite residence of Francis I. and Charles IX., and the scene of events of interest in the history of France.

— The Nuttall Encyclopedia

Rameau, Jean Philippe

French composer, born at Dijon; wrote on harmony, and, settling in Paris, composed operas, his first "Hippolyte et Aricie," and his best "Castor et Pollux" (1683-1764).

— The Nuttall Encyclopedia

Guienne

an ancient province of SW. France, now subdivided into the departments of Gironde, Dordogne, Lot, Aveyron, and embraces parts of Lot-et-Garonne and Tarn-et-Garonne.

— The Nuttall Encyclopedia

sergeant major

A senior non-commissioned appointment in the Army of a company or unit, directly responsible to the officer in charge for their soliders' performance, standards, discipline, morale, welfare, et al, that can be held by a Warrant Officer or above.

— Wiktionary

Cluny

a town in the dep. of Saône-et-Loire, on an affluent of the Saône; renowned in the Middle Ages for its Benedictine abbey, founded in 910, and the most celebrated in Europe, having been the mother establishment of 2000 others of the like elsewhere; in ecclesiastical importance it stood second to Rome, and its abbey church second to none prior to the erection of St. Peter's; a great normal school was established here in 1865.

— The Nuttall Encyclopedia

bitumen

Mineral pitch; a black, tarry substance, burning with a bright flame; Jewu2019s pitch. It occurs as an abundant natural product in many places, as on the shores of the Dead and Caspian Seas. It is used in cements, in the construction of pavements, et cetera.

— Wiktionary

Bergerac, Savinien Cyrano de

an eccentric man with comic power, a Gascon by birth; wrote a tragedy and a comedy; his best work a fiction entitled "Histoire Comique des États et Empires de la Lune et du Soleil"; fought no end of duels in vindication, it is said, of his preposterously large nose (1619-1655).

— The Nuttall Encyclopedia

Nantes

capital of the department of Loire-Inférieure, North-West France, on the Loire, 35 m. from the sea; its fine streets, handsome buildings, and historical associations make it one of the most interesting cities in France; the cathedral and the ducal castle date from the 15th century; shipbuilding, sugar-refining, and hardware are the staple industries, while an active shipping trade is kept up with the colonies.

— The Nuttall Encyclopedia

Auvergne`

an ancient province of France, united to the crown under Louis XIII. in 1610, embracing the deps. of Puy-de-Dôme, Cantal, and part of Haute-Loire, the highlands of which separate the basin of the Loire from that of the Garonne, and contain a hardy and industrious race of people descended from the original inhabitants of Gaul; they speak a strange dialect, and supply all the water-carriers and street-sweepers of Paris.

— The Nuttall Encyclopedia

Ancenis

a town on the Loire, 23 m. NE. of Nantes.

— The Nuttall Encyclopedia

Homeopathy

the art of curing, founded on resemblances; the theory and its practice that disease is cured (tuto, cito, et jucunde) by remedies which produce on a healthy person effects similar to the symptoms of the complaint under which the patient suffers, the remedies being usually administered in minute doses. This system was founded by Dr. Samuel Hahnemann, and is opposed to allopathy, or heteropathy

— Webster Dictionary

scream

A loud, emphatic, exclamation of extreme emotion, usually horror, fear, excitement et cetera. Can be the exclamation of a word, but is usually a sustained, high-pitched vowel sound, particularly /u00E6/ or /i/, in any case, the loudest and most emphatic sound a human can make tends to be a scream. The term is not generally applied to sounds made by non-humans.

— Wiktionary

hot rod

Typically a passenger vehicle modified to run and/or accelerate faster. The term may be used generically to apply to any car, truck, or motorcycle (et al.) modified for increased speed and/or performance. It may also be used to specifically describe and refer to modified cars from the original (or traditional) era of "hot rods", post World War II and prior to 1960.

— Wiktionary

Saint-Victor, Paul de

an ornate French writer, born in Paris; from 1851 was engaged in dramatic and other criticism, and established his reputation as a stylist of unusual brilliance. "When I read Saint-Victor I put on blue spectacles," said Lamartine; author of several works on historical and æsthetic subjects (e. g. "Anciens et Modernes," "Hommes et Dieux") was for a number of years General Inspector of Fine Arts (1827-1881).

— The Nuttall Encyclopedia

Armor`ica

a district of Gaul from the Loire to the Seine.

— The Nuttall Encyclopedia

Boii

an ancient people of Gaul, occupying territory between the Allier and the Loire.

— The Nuttall Encyclopedia

Allier

a confluent of the river Loire, in France, near Nevers; also the department through which it flows.

— The Nuttall Encyclopedia

Cher

an affluent of the Loire below Tours; also the dep. in France (359) to which it gives name; an agricultural and pastoral district; capital Bourges.

— The Nuttall Encyclopedia

Alford, Michael

a learned English Jesuit, left two great works, "Britannia Illustrata" and "Annales Ecclesiastici et Civiles Britannorum."

— The Nuttall Encyclopedia

étienne, St.

an important French town, capital of the dep. of the Loire, on the Furens, 35 m. SW. of Lyons; chief seat of the iron-works of France; also has noted ribbon factories.

— The Nuttall Encyclopedia

Rive-de-Gier

a flourishing town in the department of Loire, France, on the Gier, 13 m. NE. of St. Étienne; is favourably situated in the heart of a rich coal district; has manufactures of silk, glass, machinery, steel, &c.

— The Nuttall Encyclopedia

Plasma Cells

Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)

— U.S. National Library of Medicine

St. Nazaire

a flourishing seaport of France, on the Loire, 40 m. W. of Nantes, where large sums have been expended in improving its spacious docks to accommodate an increasing shipping-trade; its exports, brandy, coal, wheat, &c., are mainly from Nantes and the interior.

— The Nuttall Encyclopedia

Chartres

the capital of the French dep. of Eure-et-Lois, 55 m. SW. of Paris; gave title of Duke to the eldest of the Orleanist Bourbons.

— The Nuttall Encyclopedia

Epinay, Madame d'

a French writer, unhappily married in her youth; became notorious for her illicit intimacy with Rousseau and Grimm; her "Mémoires et Correspondence" give a lively picture of her times (1725-1783).

— The Nuttall Encyclopedia

Poitou

formerly a province in France, lying S. of the Loire, between the Vienne River and the sea; passed to England when its countess, Eleanor, married Henry I., 1152; was taken by Philip Augustus 1205, ceded to England again 1360, and retaken by Charles V. 1369.

— The Nuttall Encyclopedia

Droz, Gustav

a highly popular and brilliant novelist, born in Paris; author of "Monsieur, Madam, et Bébé," "Entre Nous," and "Cahier bleu de Mlle. Cibot" (1832-1895).

— The Nuttall Encyclopedia

Cévennes

a range of low mountains on the eastern edge of the central plateau of France, separating the basin of the Rhône from those of the Loire and Garonne; average height from 3000 to 4000 ft.; the chief scene of the dragonnades against the Huguenots under Louis XIV.

— The Nuttall Encyclopedia

Coquerel, Athanase

a Protestant pastor, son of preceding, born at Amsterdam; celebrated for his liberal and tolerant views, too much so for M. Guizot; edited Voltaire's letters on toleration; his chief work, "Jean Calas et sa Famille" (1820-1875).

— The Nuttall Encyclopedia

Amboise

a town on the Loire, 14 m. E. of Tours, with a castle, once the residence of the French kings. The Conspiracy of A., the conspiracy of Condé and the Huguenots in 1560 against Francis II., Catharine de Medici, and the Guises. The Edict of A. (1563) conceded the free exercise of their worship to the Protestants.

— The Nuttall Encyclopedia

Chanzy

a French general, born at Nouart, Ardennes; served in Algeria; commanded the army of the Loire in 1870-71; distinguished himself by his brilliant retreat from Mans to Laval; was afterwards Governor-General in Algeria; died suddenly, to the regret of his country (1823-1883).

— The Nuttall Encyclopedia

Neustria

western portion of the kingdom of the Franks in the time of the Merovingian and Carlovingian dynasties, and in constant rivalry with Austrasia (q. v.), the kingdom of the East; it extended from the Scheldt to the Loire and Soissons; Paris, Orleans, and Tours were the chief towns.

— The Nuttall Encyclopedia

Saône-et-Loire

an east-midland department of France, bounded SE. and W. by the Saône and Loire; has a fine fertile surface, and is noted for its cattle and abundant output of wine; iron and coal are wrought, and its towns are busy with the manufacture of cotton goods, pottery, machinery, &c.

— The Nuttall Encyclopedia

St. étienne

a busy industrial town of France, capital of department of Loire, on the Furens, 36 m. SW. of Lyons; has been called the "Birmingham of France"; is in the centre of a rich coal district, and produces every kind of hardware; the manufacture of ribbons is also an important industry; there is a school of mines.

— The Nuttall Encyclopedia

Vendée, La

a dep. of France, on the Bay of Biscay, S. of Loire-Inférieure; marshy on the W., wooded on the N., and with an open fertile tract in the middle and S.; it is famous as the seat of a stubborn resistance to the Revolution, and for the bloody violence with which it was suppressed.

— The Nuttall Encyclopedia

Diana de Poitiers

the mistress of Henry II. of France, for whom he built the magnificent Château d'Anet, in Eure-et-Loir; she had a great influence over him, and the cruel persecutions of the Huguenots in his reign were due to her instigation (1490-1566).

— The Nuttall Encyclopedia

Seine

the smallest but most populous department of France, entirely surrounded by the department of Seine-et-Oise; Paris and its adjacent villages cover a considerable portion of the area; presents a richly wooded, undulating surface, traversed by the Seine in a NW. direction.

— The Nuttall Encyclopedia

Périgord

an ancient territory of France, S. of Guienne, famous for its truffles, of which Périgueux (q. v.) was the capital; united to the Crown of France by Henry IV. in 1589, it is now part of the department of Dordogne and part of Lot-et-Garonne.

— The Nuttall Encyclopedia

Grétry

a celebrated musical composer, born at Liège, composed 40 operas marked by feeling and expression, the "Deux Avares," "Zemire et Azor," and "Richard Coeur de Lion" among them; he bought Rousseau's hermitage at Montmorency, where he died (1741-1813).

— The Nuttall Encyclopedia

Grolier, Jean

a famous bibliophile, whose library was dispersed in 1675; the bindings of the books being ornamented with geometric patterns, have given name to bindings in this style; they bore the inscription, "Io. Grolieri et Amicorum" (the property of Jean Grolier and his friends).

— The Nuttall Encyclopedia

Egalité, Philippe

Duke of Orleans, born April 13th, 1787, father of Louis Philippe; so called because he sided with the Republican party in the French Revolution, and whose motto was "Liberté, Fraternité, et Egalité." See Orleans, Duke of.

— The Nuttall Encyclopedia

Labé, Louise

poetess, surnamed "La belle Cordière" as the wife of a rope-maker, born in Lyons; wrote in prose "Dialogue d'Amour et de Folie," and elegies and sonnets, with "a singular approach to the ring of Shakespeare's" (1526-1566).

— The Nuttall Encyclopedia

Beyle, Marie Henri

French critic and novelist, usually known by his pseudonym "De Stendal," born at Grenoble; wrote in criticism "De l'Amour," and in fiction "La Chartreuse de Parme" and "Le Rouge et le Noir"; an ambitious writer and a cynical (1788-1842).

— The Nuttall Encyclopedia

Bracton, Henry de

an English "justice itinerant," a writer on English law of the 13th century; author of "De Legibus et Consuetudinibus Angliæ," a "Treatise on the Laws and Customs of England," and the first attempt of the kind; d. 1268.

— The Nuttall Encyclopedia

Blepharoplasty

Plastic surgery of the eyelid. (Cline et al., Dictionary of Visual Science, 4th ed)

— U.S. National Library of Medicine

Jocaste

the wife of Laius, king of Thebes, and mother of Oedipus; she afterwards married him not knowing that he was her son, and on discovery of the crime put an end to herself, though not till after she had become the mother of Etéocles, Polynices, Antigone, and Ismenë.

— The Nuttall Encyclopedia

St. Cloud

a town in the dep. of Seine-et-Oise, France; occupies an elevated site near the Seine, 10 m. W. of Paris; the fine château, built by Louis XIV.'s brother, the Duke of Orleans, was for long the favourite residence of the Emperor Napoleon, since destroyed; a part of the park is occupied by the Sèvres porcelain factory.

— The Nuttall Encyclopedia

Tonometry, Ocular

Measurement of ocular tension (INTRAOCULAR PRESSURE) with a tonometer. (Cline, et al., Dictionary of Visual Science, 4th ed)

— U.S. National Library of Medicine

Tocqueville, Alexis Clérel de

French economist, born at Verneuil, of an old Norman family, bred to the bar, and specially distinguished as the author of two works in high repute, "La Democratie en Amérique" and "L'Ancien Régime et la Révolution"; died at Cannes, leaving much of his work unfinished (1805-1861).

— The Nuttall Encyclopedia

Sully, Maximilien de Béthune, Duke of

celebrated minister of Henry IV. of France, born at the Château of Rosny, near Mantes, whence he was known at first as the Baron de Rosny; at first a ward of Henry IV. of Navarre, he joined the Huguenot ranks along with him, and distinguished himself at Coutras and Ivry, and approved of Henry's policy in changing his colours on his accession to the throne, remaining ever after by his side as most trusted adviser, directing the finances of the country with economy, and encouraging the peasantry in the cultivation of the soil; used to say, "Labourage et pasteurage, voilà les deux mamelles dont La France est alimentée, les vraies mines et trésors de Pérou," "Tillage and cattle-tending are the two paps whence France sucks nourishment; these are the true mines and treasures of Peru;" on the death of the king he retired from court, and occupied his leisure in writing his celebrated "Memoirs," which, while they show the author to be a great statesman, give no very pleasant idea of his character (1560-1611).

— The Nuttall Encyclopedia

Astrocytoma

Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)

— U.S. National Library of Medicine

Tours

a historic old town of France, on the Loire, 145 m. SW. of Paris; presents a spacious and handsome appearance, and contains a noble Gothic cathedral, archbishop's palace, Palais de Justice, besides ancient châteaux and interesting ruins; is a centre of silk and woollen manufactures, and does a large printing trade; suffered greatly by the Revocation of the Edict of Nantes and during the Franco-German War; became the seat of government after the investment of Paris and until its capitulation to the Germans.

— The Nuttall Encyclopedia

Carcinoma, Mucoepidermoid

A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)

— U.S. National Library of Medicine

Aphasia, Conduction

A type of fluent aphasia characterized by an impaired ability to repeat one and two word phrases, despite retained comprehension. This condition is associated with dominant hemisphere lesions involving the arcuate fasciculus (a white matter projection between Broca's and Wernicke's areas) and adjacent structures. Like patients with Wernicke aphasia (APHASIA, WERNICKE), patients with conduction aphasia are fluent but commit paraphasic errors during attempts at written and oral forms of communication. (From Adams et al., Principles of Neurology, 6th ed, p482; Brain & Bannister, Clinical Neurology, 7th ed, p142; Kandel et al., Principles of Neural Science, 3d ed, p848)

— U.S. National Library of Medicine

Ependymoma

Glioma derived from ependymocytes that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)

— U.S. National Library of Medicine

Sandeau, Léonard Jules

French novelist, born at Aubusson; gave up law for literature; was George Sands first "friend" in Paris, and wrote with her "Rose et Blanche"; contributed to the Revue des Deux Mondes; wrote many novels and plays, and was elected to the Academy (1858), and during his later life held the librarianship at St. Cloud (1811-1883).

— The Nuttall Encyclopedia

Orleans

on the Loire, 75 m. by rail SW. of Paris, is the capital of the province of Loiret, a trading rather than an industrial town, commerce being fostered by excellent railway, canal, and river communications; the town is of ancient date, and its streets are full of quaint wooden houses; there is an old cathedral and museum; many historic associations include the raising of the siege in 1429 by Joan of Arc, whose house is still shown, and two captures by the Germans, 1870

— The Nuttall Encyclopedia

Bichât, Marie François Xavier

an eminent French anatomist and physiologist; physician to the Hôtel-Dieu, Paris; one of the first to resolve the structure of the human body into, as "Sartor" has it, "cellular, vascular, and muscular tissues;" his great work "Anatomie Générale appliquée à la Physiologie et à la Medecine"; died at 31 (1771-1802).

— The Nuttall Encyclopedia

Puffendorf, Samuel

Baron von, eminent German jurist, born at Chemnitz, Saxony; wrote several works on jurisprudence, one of which, under the ban of Austria, was burned there by the hangman, but his "De Jure Naturæ et Gentium" is the one on which his fame rests; was successively in the service of Charles XI. of Sweden and the Elector of Brandenburg (1632-1694).

— The Nuttall Encyclopedia

Bugeaud, Thomas

marshal of France, born at Limoges; served under Napoleon; retired from service till 1830; served under Louis Philippe; contributed to the conquest of Algiers; was made governor, and created duke for his victory over the forces of the emperor of Morocco at the battle of Isly in 1844; his motto was Ense et aratro, "By sword and plough" (1784-1849).

— The Nuttall Encyclopedia

St. Malo

a strongly fortified seaport of France, on the Brittany coast (department of Ille-et-Vilaine), at the mouth of the Ranee; the old town is built over the Rocher d'Auron, an islet connected with the mainland by a causeway 215 yards long; there is a good harbour, and a considerable amount of shipping is done; potatoes, dairy-produce, and some cereals are exported. It was the birthplace of several distinguished French authors and sailors.

— The Nuttall Encyclopedia

Papilloma, Choroid Plexus

A usually benign neoplasm that arises from the cuboidal epithelium of the choroid plexus and takes the form of an enlarged CHOROID PLEXUS, which may be associated with oversecretion of CSF. The tumor usually presents in the first decade of life with signs of increased intracranial pressure including HEADACHES; ATAXIA; DIPLOPIA; and alterations of mental status. In children it is most common in the lateral ventricles and in adults it tends to arise in the fourth ventricle. Malignant transformation to choroid plexus carcinomas may rarely occur. (Adams et al., Principles of Neurology, 6th ed, p667; DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072)

— U.S. National Library of Medicine

Quesnay, François

a great French economist, born at Mérez (Seine-et-Oise), bred to the medical profession, and eminent as a medical practitioner, was consulting physician to Louis XV., but distinguished for his articles in the "Encyclopédie" on political economy, and as the founder of the Physiocratic School (q. v.), the school which attaches special importance in State economy to agriculture (1694-1774).

— The Nuttall Encyclopedia

Cambronne

French general, born at Nantes; served under the Republic and the Empire; accompanied Napoleon to Elba in 1814; commanded a division of the Old Guard at Waterloo; fought to the last; though surrounded by the enemy and summoned to surrender, refused, and was taken prisoner; is credited with the saying, La Garde meurt, et ne se rend pas, "The Guard dies, but does not surrender" (1770-1842).

— The Nuttall Encyclopedia

Rhabdomyosarcoma

A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)

— U.S. National Library of Medicine

Oligodendroglioma

A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)

— U.S. National Library of Medicine

Classical Lissencephalies and Subcortical Band Heterotopias

Disorders comprising a spectrum of brain malformations representing the paradigm of a diffuse neuronal migration disorder. They result in cognitive impairment; SEIZURES; and HYPOTONIA or spasticity. Mutations of two genes, LIS1, the gene for the non-catalytic subunit of PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB; and DCX or XLIS, the gene for doublecortin, have been identified as the most common causes of disorders in this spectrum. Additional variants of classical (Type I) lissencephaly have been linked to RELN, the gene for reelin, and ARX, the gene for aristaless related homeobox protein. (From Leventer, R.J., et al, Mol Med Today. 2000 Jul;6(7):277-84 and Barkovich, A.J., et al, Neurology. 2005 Dec 27;65(12):1873-87.)

— U.S. National Library of Medicine

Nancy

capital of the department of Meurthe-et-Moselle, North-East France, is prettily situated amid woodland scenery on the river Meurthe, 220 m. E. of Paris; the new town is spaciously laid out, while the old town, narrowed in its streets, has many interesting old buildings, e. g. the cathedral, the 16th-century palace; there is a university, and an active trade in embroidered cambric and muslin, besides cotton and woollen goods, &c.

— The Nuttall Encyclopedia

Franks

the name given in the 3rd century to a confederation of Germanic tribes, who subsequently grouped themselves into two main bodies called the Salians and the Ripuarians, the former dwelling on the Upper Rhine, and the latter on the Middle Rhine. Under their king, Clovis, the Salians overran Central Gaul, subjugating the Ripuarians, and extending their territory from the Scheldt to the Loire, whence in course of time there generally developed the kingdom of France. The Franks were of a tall and martial bearing, and thoroughly democratic in their political instincts.

— The Nuttall Encyclopedia

Pinealoma

Neoplasms which originate from pineal parenchymal cells that tend to enlarge the gland and be locally invasive. The two major forms are pineocytoma and the more malignant pineoblastoma. Pineocytomas have moderate cellularity and tend to form rosette patterns. Pineoblastomas are highly cellular tumors containing small, poorly differentiated cells. These tumors occasionally seed the neuroaxis or cause obstructive HYDROCEPHALUS or Parinaud's syndrome. GERMINOMA; CARCINOMA, EMBRYONAL; GLIOMA; and other neoplasms may arise in the pineal region with germinoma being the most common pineal region tumor. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2064; Adams et al., Principles of Neurology, 6th ed, p670)

— U.S. National Library of Medicine

Evolution, Molecular

Evolution at the molecular level of DNA sequences and proteins. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

— U.S. National Library of Medicine

Tetracyclines

Closely congeneric derivatives of the polycyclic naphthacenecarboxamide. (Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1117)

— U.S. National Library of Medicine

Versailles

a handsome city of France, capital of the department of Seine-et-Oise, 11 m. by rail SW. of Paris, of which it is virtually a suburb, and was during the monarchy, from Louis XIV.'s time, the seat of the French court; has a magnificent palace, with a gallery embracing a large collection of pictures; was occupied by the Germans during the siege of Paris, and in one of its halls the Prussian king was proclaimed emperor of Germany as William I.

— The Nuttall Encyclopedia

Carcinoma, Acinar Cell

A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)

— U.S. National Library of Medicine

Perrault, Charles

French man of letters, born in Paris; bred to the bar; distinguished as the author of inimitable fairy tales, which have immortalised his name, as "Puss in Boots," "Cinderella," "Bluebeard," &c., as also "Parallel des Anciens et des Modernes," in which his aim was to show—an ill-informed attempt—that the ancients were inferior in everything to the moderns (1628-1703).

— The Nuttall Encyclopedia

Unconsciousness

Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental stimuli. (From Adams et al., Principles of Neurology, 6th ed, pp344-5)

— U.S. National Library of Medicine

Rennes

a prosperous town in Brittany, capital of the department of Ille-et-Vilaine, situated at the junction of the Ille and the Vilaine; consists of a high and low town, separated by the river Vilaine, mostly rebuilt since the disastrous fire in 1720; has handsome buildings, a cathedral, &c.; is the seat of an archbishop, a military centre, and manufactures sail-cloth, linen, shoes, hats, &c.; where the court-martial was held which condemned Captain Dreyfus on a second trial in 1899.

— The Nuttall Encyclopedia

Alcohol Amnestic Disorder

A mental disorder associated with chronic ethanol abuse (ALCOHOLISM) and nutritional deficiencies characterized by short term memory loss, confabulations, and disturbances of attention. (Adams et al., Principles of Neurology, 6th ed, p1139)

— U.S. National Library of Medicine

Genes, Duplicate

Two identical genes showing the same phenotypic action but localized in different regions of a chromosome or on different chromosomes. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

— U.S. National Library of Medicine

Tolosa-Hunt Syndrome

An idiopathic syndrome characterized by the formation of granulation tissue in the anterior cavernous sinus or superior orbital fissure, producing a painful ophthalmoplegia. (Adams et al., Principles of Neurology, 6th ed, p271)

— U.S. National Library of Medicine

Anticipation, Genetic

The apparent tendency of certain diseases to appear at earlier AGE OF ONSET and with increasing severity in successive generations. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

— U.S. National Library of Medicine

Uvea

The pigmented vascular coat of the eyeball, consisting of the CHOROID; CILIARY BODY; and IRIS, which are continuous with each other. (Cline et al., Dictionary of Visual Science, 4th ed)

— U.S. National Library of Medicine

Hindlimb

Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)

— U.S. National Library of Medicine

Mariana, Juan

Spanish historian and political philosopher, born at Talavera; joined the Jesuits in 1554, and taught in their colleges in Rome, Sicily, and Paris; returning to Toledo he gave himself to literature; his "History of Spain" appeared in 1592 and 1605, theological writings incurred persecution, and his greatest work, "De Rege et Regis Institutione," in which he defended the right of the people to cast out a tyrant, was condemned by the general of his order (1536-1624).

— The Nuttall Encyclopedia

Echolalia

Involuntary ("parrot-like"), meaningless repetition of a recently heard word, phrase, or song. This condition may be associated with transcortical APHASIA; SCHIZOPHRENIA; or other disorders. (From Adams et al., Principles of Neurology, 6th ed, p485)

— U.S. National Library of Medicine

compress

[Unix] When used without a qualifier, generally refers to crunching of a file using a particular C implementation of compression by Joseph M. Orost et al.: and widely circulated via Usenet; use of crunch itself in this sense is rare among Unix hackers. Specifically, compress is built around the Lempel-Ziv-Welch algorithm as described in “A Technique for High Performance Data Compression”, Terry A. Welch, IEEE Computer, vol. 17, no. 6 (June 1984), pp. 8--19.

— The New Hacker's Dictionary

Duane Retraction Syndrome

A syndrome characterized by marked limitation of abduction of the eye, variable limitation of adduction and retraction of the globe, and narrowing of the palpebral fissure on attempted adduction. The condition is caused by aberrant innervation of the lateral rectus by fibers of the oculomotor nerve. There are three subtypes: type 1 (associated with loss of abduction), type 2 (associated with loss of adduction), and type 3 (loss of abduction and adduction). Two loci for Duane retraction syndrome have been located, one at chromosome 8q13 (DURS1) and another at chromosome 2q31(DURS2). It is usually caused by congenital hypoplasia of the abducens nerve or nucleus, but may rarely represent an acquired syndrome. (Adams et al., Principles of Neurology, 6th ed, p271; Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p691)

— U.S. National Library of Medicine

Delirium

A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)

— U.S. National Library of Medicine

Chromosome Disorders

Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)

— U.S. National Library of Medicine

Institute of France

was established by the Directory in 1795, to take the place of the four academies suppressed by the Convention two years previously. In 1816 Louis XVIII. gave back the old names to its four sections, viz. L'Académie Française, L'Académie des Inscriptions et Belles-lettres, L'Académie des Sciences, and L'Académie des Beaux Arts. In 1832 was added L'Académie des Sciences Morales et Politiques. Each academy has its own separate organisation and work, and participates besides in the advantages of the common library, archives, and funds. Election, which is in every case subject to government confirmation, is by ballot, and every member receives an annual salary of at least 1500 francs. Government votes a sum of money annually to the Institute. Members of the French Academy have special duties and privileges, and in some cases special remuneration. They allot every year prizes for eloquence and poetry; a prize "to the poor Frenchman who has done the most virtuous action throughout the year," and one to the Frenchman "who has written and published the book most conducive to good morals." Membership in the Académie Française is strictly limited to 40 Frenchmen. The others have, besides, from 40 to 70 members each, also Associate, foreign and corresponding, members. The Institute centralises the pursuit of all branches of knowledge and art, and has been the model of similar national institutes in Madrid, Lisbon, Stockholm, and St. Petersburg.

— The Nuttall Encyclopedia

Monoamine Oxidase Inhibitors

A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)

— U.S. National Library of Medicine

Lightfoot, John

Orientalist and divine, born at Stoke-upon-Trent, son of a clergyman, educated at Cambridge; took orders and was rector of Ashley, Staffordshire, till 1642; next year he was one of the most influential members of the Westminster Assembly; in 1652 he was made D.D., was Vice-Chancellor of Cambridge in 1653, and subsequently prebendary of Ely; one of England's earlier Hebrew scholars, the great work of his life was the "Horæ Hebraicæ et Talmudicæ," published in large part posthumously (1602-1675).

— The Nuttall Encyclopedia

Dicrocoeliidae

A family of flattened, translucent flukes (TREMATODA) occurring in the gut, gallbladder, bile ducts, liver or pancreatic ducts of amphibians, reptiles, birds, and mammals. (Noble et al., Parasitology: the Biology of Animal Parasites, 6th ed, p188)

— U.S. National Library of Medicine

Fundus Oculi

The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)

— U.S. National Library of Medicine

Berenger

or Berenga`rius, of Tours, a distinguished theologian, born at Tours; held an ecclesiastical office there, and was made afterwards archdeacon of Angers; ventured to deny the doctrine of transubstantiation, a denial for which he was condemned by successive councils of the Church, and which he was compelled more than once publicly to retract, though he so often and openly recalled his retractation that the pope, notwithstanding the opposition of the orthodox, deemed it prudent at length to let him alone. After this he ceased to trouble the Church, and retired to an island on the Loire, where he gave himself up to quiet meditation and prayer (998-1088).

— The Nuttall Encyclopedia

Actinobacteria

Class of BACTERIA with diverse morphological properties. Strains of Actinobacteria show greater than 80% 16S rDNA/rRNA sequence similarity among each other and also the presence of certain signature nucleotides. (Stackebrandt E. et al, Int. J. Syst. Bacteriol. (1997) 47:479-491)

— U.S. National Library of Medicine

Terminally Ill

Persons with an incurable or irreversible illness at the end stage that will result in death within a short time. (From O'Leary et al., Lexikon: Dictionary of Health Care Terms, Organizations, and Acronyms for the Era of Reform, 1994, p780)

— U.S. National Library of Medicine

Ophthalmodynamometry

Measurement of the blood pressure of the retinal vessels. It is used also for the determination of the near point of convergence (CONVERGENCE, OCULAR). (From Cline, et al., Dictionary of Visual Science, 4th ed)

— U.S. National Library of Medicine

Fibrocartilage

A type of CARTILAGE whose matrix contains large bundles of COLLAGEN TYPE I. Fibrocartilage is typically found in the INTERVERTEBRAL DISK; PUBIC SYMPHYSIS; TIBIAL MENISCI; and articular disks in synovial JOINTS. (From Ross et. al., Histology, 3rd ed., p132,136)

— U.S. National Library of Medicine

Peripheral Nervous System Neoplasms

Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)

— U.S. National Library of Medicine

Hydroxychloroquine

A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)

— U.S. National Library of Medicine

Friedreich Ataxia

An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)

— U.S. National Library of Medicine

Carcinoma, Small Cell

An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)

— U.S. National Library of Medicine

Cholangiocarcinoma

A malignant tumor arising from the intrahepatic bile duct epithelium. It is composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant stroma. (From Holland et al., Cancer Medicine, 3d ed, p1455; Stedman, 25th ed)

— U.S. National Library of Medicine

Meige Syndrome

A syndrome characterized by orofacial DYSTONIA; including BLEPHAROSPASM; forceful jaw opening; lip retraction; platysma muscle spasm; and tongue protrusion. It primarily affects older adults, with an incidence peak in the seventh decade of life. (From Adams et al., Principles of Neurology, 6th ed, p108)

— U.S. National Library of Medicine

Mixed Tumor, Mullerian

A tumor, basically a carcinoma with a single sarcoma such as leiomyosarcoma or angiosarcoma or multiple sarcomas of uterine origin. The role of estrogen has been postulated as a possible etiological factor in this tumor. (Holland et al., Cancer Medicine, 3d ed, p1703)

— U.S. National Library of Medicine

kamikaze packet

The ‘official’ jargon for what is more commonly called a Christmas tree packet. RFC-1025, TCP and IP Bake Off says:

See also Chernobyl packet.

— The New Hacker's Dictionary

Muscle Cramp

A sustained and usually painful contraction of muscle fibers. This may occur as an isolated phenomenon or as a manifestation of an underlying disease process (e.g., UREMIA; HYPOTHYROIDISM; MOTOR NEURON DISEASE; etc.). (From Adams et al., Principles of Neurology, 6th ed, p1398)

— U.S. National Library of Medicine

Glare

Relatively bright light, or the dazzling sensation of relatively bright light, which produces unpleasantness or discomfort, or which interferes with optimal VISION, OCULAR. (Cline et al., Dictionary of Visual Science, 4th ed)

— U.S. National Library of Medicine

Tight Junctions

Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, p22)

— U.S. National Library of Medicine

Carcinoma, Papillary, Follicular

A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)

— U.S. National Library of Medicine

Fetofetal Transfusion

Passage of blood from one fetus to another via an arteriovenous communication or other shunt, in a monozygotic twin pregnancy. It results in anemia in one twin and polycythemia in the other. (Lee et al., Wintrobe's Clinical Hematology, 9th ed, p737-8)

— U.S. National Library of Medicine

Bayle, Pierre

a native of Languedoc; first Protestant (as the son of a Calvinist minister), then Catholic, then sceptic; Professor of Philosophy at Padua, then at Rotterdam, and finally retired to the Boompjes in the latter city; known chiefly as the author of the famous Dictionnaire Historique et Critique, to the composition of which he consecrated his energies with a zeal worthy of a religious devotee, and which became the fountain-head of the sceptical philosophy that flooded France on the eve of the Revolution; pronounced by a competent judge in these matters, a mere "imbroglio of historical, philosophical, and anti-theological marine stores" (1647-1700).

— The Nuttall Encyclopedia

Microsporum

A mitosporic Oxygenales fungal genus causing various diseases of the skin and hair. The species Microsporum canis produces TINEA CAPITIS and tinea corporis, which usually are acquired from domestic cats and dogs. Teleomorphs includes Arthroderma (Nannizzia). (Alexopoulos et al., Introductory Mycology, 4th edition, p305)

— U.S. National Library of Medicine

Reflex, Pupillary

Constriction of the pupil in response to light stimulation of the retina. It refers also to any reflex involving the iris, with resultant alteration of the diameter of the pupil. (Cline et al., Dictionary of Visual Science, 4th ed)

— U.S. National Library of Medicine

Axonal Transport

The directed transport of ORGANELLES and molecules along nerve cell AXONS. Transport can be anterograde (from the cell body) or retrograde (toward the cell body). (Alberts et al., Molecular Biology of the Cell, 3d ed, pG3)

— U.S. National Library of Medicine

Birefringence

The property of nonisotropic media, such as crystals, whereby a single incident beam of light traverses the medium as two beams, each plane-polarized, the planes being at right angles to each other. (Cline et al., Dictionary of Visual Science, 4th ed)

— U.S. National Library of Medicine

Rhabdomyoma

A benign tumor derived from striated muscle. It is extremely rare, generally occurring in the tongue, neck muscles, larynx, uvula, nasal cavity, axilla, vulva, and heart. These tumors are treated by simple excision. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1354)

— U.S. National Library of Medicine

Myopathy, Central Core

An inherited congenital myopathic condition characterized by weakness and hypotonia in infancy and delayed motor development. Muscle biopsy reveals a condensation of myofibrils and myofibrillar material in the central portion of each muscle fiber. (Adams et al., Principles of Neurology, 6th ed, p1452)

— U.S. National Library of Medicine

Esophageal Sphincter, Lower

The physiologic or functional barrier to GASTROESOPHAGEAL REFLUX at the esophagogastric junction. Sphincteric muscles remain tonically contracted during the resting state and form the high-pressure zone separating the lumen of the ESOPHAGUS from that of the STOMACH. (Haubrich et al, Bockus Gastroenterology, 5th ed., pp399, 415)

— U.S. National Library of Medicine

Genetic Load

The relative amount by which the average fitness of a POPULATION is lowered, due to the presence of GENES that decrease survival, compared to the GENOTYPE with maximum or optimal fitness. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

— U.S. National Library of Medicine

Myokymia

Successive and rapid contractions of motor units associated with chronic nerve injury. The discharges arise from the peripheral aspects of regenerating nerves, and clinically impart a nearly continuous undulation of the body surface overlying the muscle. (Adams et al., Principles of Neurology, 6th ed, p1491)

— U.S. National Library of Medicine

Antigens, CD59

Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)

— U.S. National Library of Medicine

Blindness, Cortical

Total loss of vision in all or part of the visual field due to bilateral OCCIPITAL LOBE (i.e., VISUAL CORTEX) damage or dysfunction. Anton syndrome is characterized by the psychic denial of true, organic cortical blindness. (Adams et al., Principles of Neurology, 6th ed, p460)

— U.S. National Library of Medicine

Muscle Weakness

A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)

— U.S. National Library of Medicine

Nocturnal Paroxysmal Dystonia

A parasomnia characterized by paroxysmal episodes of choreoathetotic, ballistic, dystonic movements, and semipurposeful activity. The episodes occur during non-rapid eye movement sleep and typically recur several times per night. (Neurology 1992 Jul;42(7 Suppl 6):61-67; Adams et al., Principles of Neurology, 6th ed, p391)

— U.S. National Library of Medicine

Echinostomatidae

A family of flukes (TREMATODA) characterized by a collar of spines at their anterior end. The body is elongated and is covered with spines, and the two suckers are usually close together. (Noble et al., Parasitology: the Biology of Animal Parasites, 6th ed, p183)

— U.S. National Library of Medicine

Subcellular Fractions

Components of a cell produced by various separation techniques which, though they disrupt the delicate anatomy of a cell, preserve the structure and physiology of its functioning constituents for biochemical and ultrastructural analysis. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p163)

— U.S. National Library of Medicine

Myelin-Associated Glycoprotein

A myelin protein found in the periaxonal membrane of both the central and peripheral nervous systems myelin sheaths. It has a structure that is similar to members of the Ig superfamily that participate in cell adhesion. (From Siegel et al., Basic Neurochemistry, 5th ed, p132)

— U.S. National Library of Medicine

Perivascular Epithelioid Cell Neoplasms

A family of mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. These cells do not have a normal anatomic homolog. (From Fletcher CDM, et. al., World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone, 2002).

— U.S. National Library of Medicine

Guichard, Karl

a Prussian officer, born at Magdeburg; joined Frederick the Great at Breslau, "a solid staid man, of a culture unusual for a soldier; brought with him his book, 'Memoirs Militaires sur les Grecs et les Romans,' a solid account of the matter by the first man who ever understood both war and Greek; very welcome to Frederick, whom he took to very warmly; dubbed him Quintus Icilius, and had his name so entered as major on the army books; promoted at length to colonel, a rank he held till the end of the war" (1721-1775). See Carlyle's "Frederick."

— The Nuttall Encyclopedia

Mixed Tumor, Mesodermal

A sarcoma of the body of the uterus arising in older women, composed of more than one mesenchymal tissue, especially including striated muscle cells. It is associated with previous pelvic radiation exposure in 20% of patients. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1702)

— U.S. National Library of Medicine

Paraneoplastic Polyneuropathy

A diffuse or multifocal peripheral neuropathy related to the remote effects of a neoplasm, most often carcinoma or lymphoma. Pathologically, there are inflammatory changes in peripheral nerves. The most common clinical presentation is a symmetric distal mixed sensorimotor polyneuropathy. (Adams et al., Principles of Neurology, 6th ed, p1334)

— U.S. National Library of Medicine

Amaurosis Fugax

Transient complete or partial monocular blindness due to retinal ischemia. This may be caused by emboli from the CAROTID ARTERY (usually in association with CAROTID STENOSIS) and other locations that enter the central RETINAL ARTERY. (From Adams et al., Principles of Neurology, 6th ed, p245)

— U.S. National Library of Medicine

Pain Insensitivity, Congenital

A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from nonnoxious stimuli. Absent corneal reflexes and MENTAL RETARDATION may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343)

— U.S. National Library of Medicine

Optic Disk Drusen

Optic disk bodies composed primarily of acid mucopolysaccharides that may produce pseudopapilledema (elevation of the optic disk without associated INTRACRANIAL HYPERTENSION) and visual field deficits. Drusen may also occur in the retina (see RETINAL DRUSEN). (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p355)

— U.S. National Library of Medicine

Porcine Reproductive and Respiratory Syndrome

A syndrome characterized by outbreaks of late term abortions, high numbers of stillbirths and mummified or weak newborn piglets, and respiratory disease in young unweaned and weaned pigs. It is caused by PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS. (Radostits et al., Veterinary Medicine, 8th ed, p1048)

— U.S. National Library of Medicine

Hemifacial Spasm

Recurrent clonic contraction of facial muscles, restricted to one side. It may occur as a manifestation of compressive lesions involving the seventh cranial nerve (FACIAL NERVE DISEASES), during recovery from BELL PALSY, or in association with other disorders. (From Adams et al., Principles of Neurology, 6th ed, p1378)

— U.S. National Library of Medicine

Korsakoff Syndrome

An acquired cognitive disorder characterized by inattentiveness and the inability to form short term memories. This disorder is frequently associated with chronic ALCOHOLISM; but it may also result from dietary deficiencies; CRANIOCEREBRAL TRAUMA; NEOPLASMS; CEREBROVASCULAR DISORDERS; ENCEPHALITIS; EPILEPSY; and other conditions. (Adams et al., Principles of Neurology, 6th ed, p1139)

— U.S. National Library of Medicine

DNA Footprinting

A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

— U.S. National Library of Medicine

Papilledema

Swelling of the OPTIC DISK, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins. Chronic papilledema may cause OPTIC ATROPHY and visual loss. (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p175)

— U.S. National Library of Medicine

Mesenchymoma

A mixed mesenchymal tumor composed of two or more mesodermal cellular elements not commonly associated, not counting fibrous tissue as one of the elements. Mesenchymomas are widely distributed in the body and about 75% are malignant. (Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866)

— U.S. National Library of Medicine

Conidiobolus

A genus of fungi in the family Ancylistaceae, order ENTOMOPHTHORALES, characterized by the presence of small nuclei with a prominent central nucleolus in interphase. They are commonly found in the soil but also infect termites, aphids, and sometimes, though rarely, mammals including humans. (Alexopoulos et al, Introductory Mycology, 4th ed, pp159-60)

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Antigens, CD5

Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)

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Fibroma, Desmoplastic

A extremely rare bone tumor characterized by abundant collagen formation and a fibrous stroma, without evidence of mitosis or pleomorphism. It appears on x-rays as an osteolytic lesion with well-defined margins and must be differentiated from primary fibrosarcoma of bone. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1441)

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Germinoma

A malignant neoplasm of the germinal tissue of the GONADS; MEDIASTINUM; or pineal region. Germinomas are uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular eosinophilic-staining cytoplasm. (Stedman, 265th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1642-3)

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Spina Bifida Cystica

A form of spinal dysraphism associated with a protruding cyst made up of either meninges (i.e., a MENINGOCELE) or meninges in combination with spinal cord tissue (i.e., a MENINGOMYELOCELE). These lesions are frequently associated with spinal cord dysfunction, HYDROCEPHALUS, and SYRINGOMYELIA. (From Davis et al., Textbook of Neuropathology, 2nd ed, pp224-5)

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Syncope

A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)

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Bicyclo Compounds, Heterocyclic

A class of saturated compounds consisting of two rings only, having two or more atoms in common, containing at least one hetero atom, and that take the name of an open chain hydrocarbon containing the same total number of atoms. (From Riguady et al., Nomenclature of Organic Chemistry, 1979, p31)

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Mesenteric Vascular Occlusion

Obstruction of the flow in the SPLANCHNIC CIRCULATION by ATHEROSCLEROSIS; EMBOLISM; THROMBOSIS; STENOSIS; TRAUMA; and compression or intrinsic pressure from adjacent tumors. Rare causes are drugs, intestinal parasites, and vascular immunoinflammatory diseases such as PERIARTERITIS NODOSA and THROMBOANGIITIS OBLITERANS. (From Juergens et al., Peripheral Vascular Diseases, 5th ed, pp295-6)

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Bayard, Chevalier de

an illustrious French knight, born in the Château Bayard, near Grenoble; covered himself with glory in the wars of Charles VIII., Louis XII., and Francis I.; his bravery and generosity commanded the admiration of his enemies, and procured for him the thrice-honourable cognomen of "The Knight sans peur et sans reproche"; one of his most brilliant feats was his defence, single-handed, of the bridge over the Garigliano, in the face of a large body of Spaniards; was mortally wounded defending a pass at Abblategrasso; fell with his face to the foe, who carried off his body, but restored it straightway afterwards for due burial by his friends (1476-1524).

— The Nuttall Encyclopedia

Poliomyelitis, Bulbar

A form of paralytic poliomyelitis affecting neurons of the MEDULLA OBLONGATA of the brain stem. Clinical features include impaired respiration, HYPERTENSION, alterations of vasomotor control, and dysphagia. Weakness and atrophy of the limbs and trunk due to spinal cord involvement is usually associated. (From Adams et al., Principles of Neurology, 6th ed, p765)

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Lichenoid Eruptions

Conditions in which there is histological damage to the lower epidermis along with a grouped chronic inflammatory infiltrate in the papillary dermis disturbing the interface between the epidermis and dermis. LICHEN PLANUS is the prototype of all lichenoid eruptions. (From Rook et al., Textbook of Dermatology, 4th ed, p398)

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Polyribosomes

A multiribosomal structure representing a linear array of RIBOSOMES held together by messenger RNA; (RNA, MESSENGER); They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

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HL-60 Cells

A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)

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Dementia, Multi-Infarct

Loss of higher cortical functions with retained awareness due to multiple cortical or subcortical CEREBRAL INFARCTION. Memory, judgment, attention span, and impulse control are often impaired, and may be accompanied by PSEUDOBULBAR PALSY; HEMIPARESIS; reflex abnormalities, and other signs of localized neurologic dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p1060)

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Pleurotus

A genus of basidiomycetous fungi, family POLYPORACEAE, order POLYPORALES, that grows on logs or tree stumps in shelflike layers. The species P. ostreatus, the oyster mushroom, is a choice edible species and is the most frequently encountered member of the genus in eastern North America. (Alexopoulos et al., Introductory Mycology, 4th ed, p531)

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Myoclonus

Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles. This condition may be a feature of some CENTRAL NERVOUS SYSTEM DISEASES; (e.g., EPILEPSY, MYOCLONIC). Nocturnal myoclonus is the principal feature of the NOCTURNAL MYOCLONUS SYNDROME. (From Adams et al., Principles of Neurology, 6th ed, pp102-3).

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Hyperalgesia

An increased sensation to painful stimuli that may follow damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve. Hyperalgesia can occur both at the site of tissue damage (primary hyperalgesia) and in the surrounding undamaged areas (secondary hyperalgesia). (Kandel et al., Principles of Neural Science, 3d ed, p386)

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Causalgia

A complex regional pain syndrome characterized by burning pain and marked sensitivity to touch (HYPERESTHESIA) in the distribution of an injured peripheral nerve. Autonomic dysfunction in the form of sudomotor (i.e., sympathetic innervation to sweat glands), vasomotor, and trophic skin changes may also occur. (Adams et al., Principles of Neurology, 6th ed, p1359)

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Pantothenate Kinase-Associated Neurodegeneration

A rare autosomal recessive degenerative disorder which usually presents in late childhood or adolescence. Clinical manifestations include progressive MUSCLE SPASTICITY; hyperreflexia; MUSCLE RIGIDITY; DYSTONIA; DYSARTHRIA; and intellectual deterioration which progresses to severe dementia over several years. (From Adams et al., Principles of Neurology, 6th ed, p972; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp972-929)

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RNA

A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

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Tonic Pupil

A pupillary abnormality characterized by a poor pupillary light reaction, reduced accommodation, iris sector palsies, an enhanced pupillary response to near effort that results in a prolonged, "tonic" constriction, and slow pupillary redilation. This condition is associated with injury to the postganglionic parasympathetic innervation to the pupil. (From Miller et al., Clinical Neuro-Ophthalmology, 4th ed, pp492-500)

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Mitochondrial Encephalomyopathies

A heterogenous group of disorders characterized by alterations of mitochondrial metabolism that result in muscle and nervous system dysfunction. These are often multisystemic and vary considerably in age at onset (usually in the first or second decade of life), distribution of affected muscles, severity, and course. (From Adams et al., Principles of Neurology, 6th ed, pp984-5)

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Vestibular Neuronitis

Idiopathic inflammation of the VESTIBULAR NERVE, characterized clinically by the acute or subacute onset of VERTIGO; NAUSEA; and imbalance. The COCHLEAR NERVE is typically spared and HEARING LOSS and TINNITUS do not usually occur. Symptoms usually resolve over a period of days to weeks. (Adams et al., Principles of Neurology, 6th ed, p304)

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Lymphangiosarcoma

A malignant tumor originating from the endothelial cells of lymphatic vessels. Most lymphangiosarcomas arise in an arm secondary to radical mastectomy but they sometimes complicate idiopathic lymphedema. The lymphedema has usually been present for 6 to 10 years before malignant changes develop. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866)

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Virulence Factors

Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)

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Agraphia

Loss or impairment of the ability to write (letters, syllables, words, or phrases) due to an injury to a specific cerebral area or occasionally due to emotional factors. This condition rarely occurs in isolation, and often accompanies APHASIA. (From Adams et al., Principles of Neurology, 6th ed, p485; APA, Thesaurus of Psychological Index Terms, 1994)

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Carcinoma, Embryonal

A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)

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Myopathies, Nemaline

A group of inherited congenital myopathic conditions characterized clinically by weakness, hypotonia, and prominent hypoplasia of proximal muscles including the face. Muscle biopsy reveals large numbers of rod-shaped structures beneath the muscle fiber plasma membrane. This disorder is genetically heterogeneous and may occasionally present in adults. (Adams et al., Principles of Neurology, 6th ed, p1453)

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Neuroma, Acoustic

A benign SCHWANNOMA of the eighth cranial nerve (VESTIBULOCOCHLEAR NERVE), mostly arising from the vestibular branch (VESTIBULAR NERVE) during the fifth or sixth decade of life. Clinical manifestations include HEARING LOSS; HEADACHE; VERTIGO; TINNITUS; and FACIAL PAIN. Bilateral acoustic neuromas are associated with NEUROFIBROMATOSIS 2. (From Adams et al., Principles of Neurology, 6th ed, p673)

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Myelitis, Transverse

Inflammation of a transverse portion of the spinal cord characterized by acute or subacute segmental demyelination or necrosis. The condition may occur sporadically, follow an infection or vaccination, or present as a paraneoplastic syndrome (see also ENCEPHALOMYELITIS, ACUTE DISSEMINATED). Clinical manifestations include motor weakness, sensory loss, and incontinence. (Adams et al., Principles of Neurology, 6th ed, pp1242-6)

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Aqueous Humor

The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319)

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Apraxia, Ideomotor

A form of apraxia characterized by an acquired inability to carry out a complex motor activity despite the ability to mentally formulate the action. This condition has been attributed to a disruption of connections between the dominant parietal cortex and supplementary and premotor cortical regions in both hemispheres. (From Adams et al., Principles of Neurology, 6th ed, p57)

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Cerebellar Ataxia

Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)

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Pepin the Short

king of the Franks, was the son of Charles Martel, and at first shared with his brother Carloman the viceroyalty of the kingdom under Hilderik III.; in 747 Carloman retired to a monastery, and five years later Pepin deposed Hilderik and ascended the throne; his kingdom embraced the valleys of the Rhine, the Rhône, and the Seine; he united his interests with those of the Church, and in 756 entered Italy to rescue the Pope from the threatened domination of the Lombards; reduced Aistulf of Lombardy to vassalage, assumed the title of Patrician of Rome, and by bestowing on Pope Stephen III. the "Exarchate" of the Roman empire, laid the foundation of papal temporal sovereignty, five cities being placed under his jurisdiction; his subsequent exploits included the conquest of the Loire Valley and the expulsion of the Moors from France; his fame was overshadowed by that of his son Charlemagne; d. 678.

— The Nuttall Encyclopedia

Amyloid Neuropathies

Disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. Familial, primary (nonfamilial), and secondary forms have been described. Some familial subtypes demonstrate an autosomal dominant pattern of inheritance. Clinical manifestations include sensory loss, mild weakness, autonomic dysfunction, and CARPAL TUNNEL SYNDROME. (Adams et al., Principles of Neurology, 6th ed, p1349)

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Diet, Fat-Restricted

A diet that contains limited amounts of fat with less than 30% of calories from all fats and less than 10% from saturated fat. Such a diet is used in control of HYPERLIPIDEMIAS. (From Bondy et al, Metabolic Control and Disease, 8th ed, pp468-70; Dorland, 27th ed)

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Souza, Madame de

French novelist, born in Paris, and educated in a convent, on her leaving which she was married to the Comte de Flahaut, a man much older than herself, and with whom she lived unhappily; fled to Germany and then to England on the outbreak of the Revolution; afterwards returned to Paris, and as the wife of the Marquis de Souza-Botelho presided over one of the most charming of salons, in which the chief attraction was her own bright and gifted personality; her novels, "Eugène de Rothelin," "Eugénie et Mathilde," etc., breathe the spirit of the old régime, and are full of natural and vivacious pictures of French life (1761-1836).

— The Nuttall Encyclopedia

Uveomeningoencephalitic Syndrome

A syndrome characterized by bilateral granulomatous UVEITIS with IRITIS and secondary GLAUCOMA, premature ALOPECIA, symmetrical VITILIGO, poliosis circumscripta (a strand of depigmented hair), HEARING DISORDERS, and meningeal signs (neck stiffness and headache). Examination of the cerebrospinal fluid reveals a pattern consistent with MENINGITIS, ASEPTIC. (Adams et al., Principles of Neurology, 6th ed, p748; Surv Ophthalmol 1995 Jan;39(4):265-292)

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Anesthetics, Dissociative

Intravenous anesthetics that induce a state of sedation, immobility, amnesia, and marked analgesia. Subjects may experience a strong feeling of dissociation from the environment. The condition produced is similar to NEUROLEPTANALGESIA, but is brought about by the administration of a single drug. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed)

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Anterior Chamber

The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)

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Chondrosarcoma, Mesenchymal

A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)

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Cavernous Sinus Thrombosis

Formation or presence of a blood clot (THROMBUS) in the CAVERNOUS SINUS of the brain. Infections of the paranasal sinuses and adjacent structures, CRANIOCEREBRAL TRAUMA, and THROMBOPHILIA are associated conditions. Clinical manifestations include dysfunction of cranial nerves III, IV, V, and VI, marked periorbital swelling, chemosis, fever, and visual loss. (From Adams et al., Principles of Neurology, 6th ed, p711)

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Olfactory Nerve Diseases

Diseases of the first cranial (olfactory) nerve, which usually feature anosmia or other alterations in the sense of smell and taste. Anosmia may be associated with NEOPLASMS; CENTRAL NERVOUS SYSTEM INFECTIONS; CRANIOCEREBRAL TRAUMA; inherited conditions; toxins; METABOLIC DISEASES; tobacco abuse; and other conditions. (Adams et al., Principles of Neurology, 6th ed, pp229-31)

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Paralysis

A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)

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Myelin Proteolipid Protein

A myelin protein that is the major component of the organic solvent extractable lipoprotein complexes of whole brain. It has been the subject of much study because of its unusual physical properties. It remains soluble in chloroform even after essentially all of its bound lipids have been removed. (From Siegel et al., Basic Neurochemistry, 4th ed, p122)

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Nystagmus, Congenital

Nystagmus present at birth or caused by lesions sustained in utero or at the time of birth. It is usually pendular, and is associated with ALBINISM and conditions characterized by early loss of central vision. Inheritance patterns may be X-linked, autosomal dominant, or recessive. (Adams et al., Principles of Neurology, 6th ed, p275)

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Amnesia

Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)

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Antigens, CD29

Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)

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Carcinoma, Medullary

A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)

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Striatonigral Degeneration

A sporadic neurodegenerative disease with onset in middle-age characterized clinically by Parkinsonian features (e.g., MUSCLE RIGIDITY; HYPOKINESIA; stooped posture) and HYPOTENSION. This condition is considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Pathologic features include a prominent loss of neurons in the zona compacta of the SUBSTANTIA NIGRA and PUTAMEN. (From Adams et al., Principles of Neurology, 6th ed, p1075-6)

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Ganglioneuroma

A benign neoplasm that usually arises from the sympathetic trunk in the mediastinum. Histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. The tumor may present clinically with HORNER SYNDROME or diarrhea due to ectopic production of vasoactive intestinal peptide. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p966)

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Optic Nerve Glioma

Glial cell derived tumors arising from the optic nerve, usually presenting in childhood. Roughly 50% are associated with NEUROFIBROMATOSIS 1. Clinical manifestations include decreased visual acuity; EXOPHTHALMOS; NYSTAGMUS, PATHOLOGIC; STRABISMUS; pallor or swelling of the optic disc; and INTRACRANIAL HYPERTENSION. The tumor may extend into the optic chiasm and hypothalamus. (Adams et al., Principles of Neurology, 6th ed, p681)

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MPTP Poisoning

A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)

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Gerstmann Syndrome

A disorder of cognition characterized by the tetrad of finger agnosia, dysgraphia, dyscalculia, and right-left disorientation. The syndrome may be developmental or acquired. Acquired Gerstmann syndrome is associated with lesions in the dominant (usually left) PARIETAL LOBE which involve the angular gyrus or subjacent white matter. (From Adams et al., Principles of Neurology, 6th ed, p457)

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Histiocytoma, Benign Fibrous

A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)

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Vasculitis, Central Nervous System

Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)

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Cataplexy

A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396)

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Kearns-Sayre Syndrome

A mitochondrial disorder featuring the triad of chronic progressive EXTERNAL OPHTHALMOPLEGIA, cardiomyopathy (CARDIOMYOPATHIES) with conduction block (HEART BLOCK), and RETINITIS PIGMENTOSA. Disease onset is in the first or second decade. Elevated CSF protein, sensorineural deafness, seizures, and pyramidal signs may also be present. Ragged-red fibers are found on muscle biopsy. (Adams et al., Principles of Neurology, 6th ed, p984)

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MERRF Syndrome

A mitochondrial encephalomyopathy characterized clinically by a mixed seizure disorder, myoclonus, progressive ataxia, spasticity, and a mild myopathy. Dysarthria, optic atrophy, growth retardation, deafness, and dementia may also occur. This condition tends to present in childhood and to be transmitted via maternal lineage. Muscle biopsies reveal ragged-red fibers and respiratory chain enzymatic defects. (From Adams et al., Principles of Neurology, 6th ed, p986)

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