Definitions containing e├ tv├ s, jozsef
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Selegiline is a drug used for the treatment of early-stage Parkinson's disease, depression and senile dementia. In normal clinical doses it is a selective irreversible MAO-B inhibitor. However, in larger doses it loses its specificity and also inhibits MAO-A. Dietary restrictions are common for MAOI treatments, but special dietary restrictions for lower doses have been found to be unnecessary, and dietary restrictions appear to be unnecessary at standard doses when selegiline is taken as Emsam, the transdermal patch form, as no adverse events due to diet have ever been reported with Emsam. The drug was discovered by Jozsef Knoll et al. in Hungary. Selegiline belongs to a class of drugs called phenethylamines. Selegiline is a levomethamphetamine derivative with a propargyl group attached to the nitrogen atom.
Joseph Pulitzer, born Pulitzer J├│zsef, was a Hungarian-American Jewish newspaper publisher of the St. Louis Post Dispatch and the New York World. Pulitzer introduced the techniques of "new journalism" to the newspapers he acquired in the 1880s. He became a leading national figure in the Democratic Party and was elected Congressman from New York. He crusaded against big business and corruption. In the 1890s the fierce competition between his World and William Randolph Hearst's New York Journal caused both to use yellow journalism for wider appeal; it opened the way to mass-circulation newspapers that depended on advertising revenue and appealed to readers with multiple forms of news, entertainment and advertising. Today, he is best known for the Pulitzer Prizes, which were established by money he bequeathed to Columbia University, as was the Columbia School of Journalism. The prizes are given annually to award achievements in journalism and photography, as well as literature and history, poetry, music and drama.
John Stephen Hirsch, OC was an Hungarian-Canadian theater director. He was born in Si├│fok, Hungary to J├│zsef and Ilona Hirsch, both of whom perished in The Holocaust along with his younger brother Istv├ín. Hirsch survived after spending most of the Second World War years in Budapest, and came to Canada in 1947 through the War Orphans Project of the Canadian Jewish Congress. Arriving in Winnipeg, Hirsch was taken into the home of Alex and Pauline Shack. He remained close to the Shacks for the rest of his life, and although he lived in New York and Toronto, maintained strong ties with the city of Winnipeg. In 1957, Hirsch and Tom Hendry co-founded Theatre 77, which they combined with the Winnipeg Little Theatre in 1958 to form the Manitoba Theatre Centre with Hirsch as artistic director and Hendry as manager. MTC became an influential model for regional theatres across Canada and the United States, and is one of Hirsch's most important contributions to Canadian theatre. He directed many plays and musicals at MTC, which he left in 1965. Over the years, he directed at many Canadian theatres such as Toronto's Crest Theatre, the National Arts Centre, Young People's Theatre, and the Shaw Festival. His 1976 production of Three Sisters at the Stratford Festival, with Maggie Smith, Martha Henry and Marti Maraden in the title roles, won great acclaim.