Definitions for xanthineˈzæn θin, -θɪn
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crystalline oxidation product of the metabolism of nucleoproteins; precursor of uric acid; found in many organs and in urine
Any of a group of alkaloids, that include caffeine, theophylline, and theobromine as well as the parent compound, a precursor of uric acid found in many organs of the body.
Xanthine, is a purine base found in most human body tissues and fluids and in other organisms. A number of stimulants are derived from xanthine, including caffeine and theobromine. Xanthine is a product on the pathway of purine degradation. ⁕It is created from guanine by guanine deaminase. ⁕It is created from hypoxanthine by xanthine oxidoreductase. ⁕It is also created from xanthosine by purine nucleoside phosphorylase. Xanthine is subsequently converted to uric acid by the action of the xanthine oxidase enzyme. Studies reported in 2008, based on ¹²C/¹³C isotopic ratios of organic compounds found in the Murchison meteorite, suggested that xanthine and related chemicals, including the RNA component uracil, were formed extraterrestrially. In August 2011, a report, based on NASA studies with meteorites found on Earth, was published suggesting xanthine and related organic molecules, including the DNA and RNA components adenine and guanine, were made in outer space.
U.S. National Library of Medicine
A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)
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