What does wortmannin mean?
Definitions for wortmannin
wort·man·nin
This dictionary definitions page includes all the possible meanings, example usage and translations of the word wortmannin.
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Wiktionary
wortmanninnoun
A furanosteroid metabolite of the fungus Penicillium funiculosum; it is an inhibitor of some kinases
Wikidata
Wortmannin
Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces wortmannii, is a specific, covalent inhibitor of phosphoinositide 3-kinases. It has an in vitro inhibitory concentration of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. It displays a similar potency in vitro for the class I, II, and III PI3K members although it can also inhibit other PI3K-related enzymes such as mTOR, DNA-PK, some phosphatidylinositol 4-kinases, myosin light chain kinase and mitogen-activated protein kinase at high concentrations, Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K. The half-life of wortmannin in tissue culture is about 10 minutes due to the presence of the highly reactive C20 carbon that is also responsible for its ability to covalently inactivate PI3K. Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation.
Numerology
Chaldean Numerology
The numerical value of wortmannin in Chaldean Numerology is: 4
Pythagorean Numerology
The numerical value of wortmannin in Pythagorean Numerology is: 6
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"wortmannin." Definitions.net. STANDS4 LLC, 2024. Web. 19 Apr. 2024. <https://www.definitions.net/definition/wortmannin>.
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