Definitions for wolff-parkinson-white syndrome

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U.S. National Library of Medicine

  1. Wolff-Parkinson-White Syndrome

    A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulse conducts to the HEART VENTRICLES via an accessory pathway located between the wall of the right or left atria and the ventricles, known as the bundle of Kent. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.

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  1. Wolff–Parkinson–White syndrome

    Wolff–Parkinson–White syndrome is one of several disorders of the conduction system of the heart that are commonly referred to as pre-excitation syndromes. WPW is caused by the presence of an abnormal accessory electrical conduction pathway between the atria and the ventricles. Electrical signals traveling down this abnormal pathway may stimulate the ventricles to contract prematurely, resulting in a unique type of supraventricular tachycardia referred to as an atrioventricular reciprocating tachycardia. The prevalence of WPW is between 0.1% and 0.3% in the general population. Sudden cardiac death in people with WPW is rare, and is usually caused by the propagation of an atrial tachydysrhythmia to the ventricles by the abnormal accessory pathway.

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