Definitions for warfarinˈwɔr fə rɪn
This page provides all possible meanings and translations of the word warfarin
Random House Webster's College Dictionary
war•fa•rinˈwɔr fə rɪn(n.)
a crystalline anticoagulant, C19H16O4, used as a rodenticide.
a preparation of this used in the management of clotting disorders.
Origin of warfarin:
1945–50; W(isconsin)A(lumni)R(esearch)F(oundation) (owners of patent) + (coum )arin
an anticoagulant (trade name Coumadin) use to prevent and treat a thrombus or embolus
An anticoagulant medication that is used for the prophylaxis of thrombosis and embolism in many disorders.
Warfarin is an anticoagulant normally used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body respectively. It was initially introduced in 1948 as a pesticide against rats and mice and is still used for this purpose, although more potent poisons such as brodifacoum have since been developed. In the early 1950s warfarin was found to be effective and relatively safe for preventing thrombosis and embolism in many disorders. It was approved for use as a medication in 1954 and has remained popular ever since; warfarin is the most widely prescribed oral anticoagulant drug in North America. Despite its effectiveness, treatment with warfarin has several shortcomings. Many commonly used medications interact with warfarin, as do some foods and its activity has to be monitored by blood testing for the international normalized ratio to ensure an adequate yet safe dose is taken. A high INR predisposes to a high risk of bleeding, while an INR below the therapeutic target indicates that the dose of warfarin is insufficient to protect against thromboembolic events.
U.S. National Library of Medicine
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
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