Definitions for wagr syndrome

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  1. WAGR syndrome

    WAGR syndrome is a rare genetic syndrome in which affected children are predisposed to develop Wilms tumour, Aniridia, Genitourinary anomalies, and mental Retardation. The G is sometimes instead given as "gonadoblastoma," since the genitourinary anomalies are tumours of the gonads. A subset of WAGR syndrome patients shows severe childhood obesity; the acronym WAGRO has been used to describe this category. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring genes.

U.S. National Library of Medicine

  1. WAGR Syndrome

    A contiguous gene syndrome associated with hemizygous deletions of chromosome region 11p13. The condition is marked by the combination of WILMS TUMOR; ANIRIDIA; GENITOURINARY ABNORMALITIES; and MENTAL RETARDATION.

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