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Definitions for von hippel-lindau tumor suppressor protein

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U.S. National Library of Medicine

  1. Von Hippel-Lindau Tumor Suppressor Protein

    A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.

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