Definitions for von hippel-lindau disease
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Von Hippel-Lindau disease
Von Hippel–Lindau disease is a rare, autosomal dominant genetic condition that predisposes individuals to benign and malignant tumours. The most common tumours found in VHL are central nervous system and retinal hemangioblastomas, clear cell renal carcinomas, pheochromocytomas, pancreatic neuroendocrine tumours, pancreatic cysts, endolymphatic sac tumors and epididymal papillary cystadenomas. VHL results from a mutation in the von Hippel–Lindau tumor suppressor gene on chromosome 3p25.3.
U.S. National Library of Medicine
von Hippel-Lindau Disease
An autosomal dominant disorder caused by mutations in a tumor suppressor gene. This syndrome is characterized by abnormal growth of small blood vessels leading to a host of neoplasms. They include HEMANGIOBLASTOMA in the RETINA; CEREBELLUM; and SPINAL CORD; PHEOCHROMOCYTOMA; pancreatic tumors; and renal cell carcinoma (see CARCINOMA, RENAL CELL). Common clinical signs include HYPERTENSION and neurological dysfunctions.
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"von hippel-lindau disease." Definitions.net. STANDS4 LLC, 2014. Web. 16 Sep. 2014. <http://www.definitions.net/definition/von hippel-lindau disease>.