Definitions for vancomycin
This page provides all possible meanings and translations of the word vancomycin
an antibiotic (trade name Vancocin) effective against some bacterial infections
A glycopeptide antibiotic, produced by the actinomycete Amycolaptosis orientalis, used against Gram-positive bacteria, especially staphylococci and enterococci.
Vancomycin INN is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria. Vancomycin was first isolated in 1953 at Eli Lilly, from a soil sample collected from the interior jungles of Borneo by a missionary. It is a naturally occurring antibiotic made by the soil bacterium Actinobacteria species Amycolatopsis orientalis. It is a complex chemical compound and an example of a comparatively rare haloorganic natural compound, containing two covalently bonded chlorine atoms. The compound was industrially produced by fermentation and given the generic name vancomycin, derived from the term "vanquish." The original indication for vancomycin was for the treatment of penicillin-resistant Staphylococcus aureus, a use kept alive for many years by the fact that compound had to be given intravenously and thus provided bacteria fewer opportunities to evolve resistance, and the fact that organisms were relatively slow to evolve to adapt to it, even in experiments. For many years since its initial use, vancomycin has traditionally been reserved as a drug of "last resort", used only after treatment with other antibiotics had failed. Recently, however, vancomycin resistant organisms are becoming common. Thus, vancomycin is increasingly being displaced from this role by newer antibiotics such as linezolid, daptomycin, and quinupristin/dalfopristin.
U.S. National Library of Medicine
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
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