Definitions for urocanate hydratase

This page provides all possible meanings and translations of the word urocanate hydratase

U.S. National Library of Medicine

  1. Urocanate Hydratase

    An enzyme that catalyzes the conversion of 4,5-dihydro-4-oxo-5-imidazolepropanoate to urocanate and water. EC


  1. Urocanase

    Urocanase is the enzyme that catalyzes the second step in the degradation of histidine, the hydration of urocanate into imidazolonepropionate. urocanate + H₂O 4,5-dihydro-4-oxo-5-imidazolepropanoate Inherited deficiency of urocanase leads to elevated levels of urocanic acid in the urine, a condition known as urocanic aciduria. Urocanase is found in some bacteria, in the liver of many vertebrates and has also been found in the plant Trifolium repens. Urocanase is a protein of about 60 Kd, it binds tightly to NAD⁺ and uses it as an electrophil cofactor. A conserved cysteine has been found to be important for the catalytic mechanism and could be involved in the binding of the NAD⁺.


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