Definitions for tyrothricin
This page provides all possible meanings and translations of the word tyrothricin
a mixture of antibiotics applied locally to infections caused by Gram-positive bacteria
a mixture of the antibiotics tyrocidine and gramicidin, used topically to treat gram-positive bacterial infections
Tyrothricin is a cyclic polypeptide-antibiotic mixture from Bacillus brevis. It is a locally effective antibiotic effective against gram-positive bacteria. It is sometimes combined with benzocaine 5 mg to provide relief from sore throats. In systemic intake it can lead to severe side effects, therefore, the use is limited to topical application. Tyrothricin belongs to the pharmacologically related group of polypeptide antibiotic compounds including colistin, polymyxin B and bacitracin. There are no cross-resistance to these three agents.
U.S. National Library of Medicine
A polypeptide antibiotic mixture obtained from Bacillus brevis. It consists of a mixture of three tyrocidines (60%) and several gramicidins (20%) and is very toxic to blood, liver, kidneys, meninges, and the olfactory apparatus. It is used topically.
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