Definitions for tumor necrosis factor

This page provides all possible meanings and translations of the word tumor necrosis factor

Random House Webster's College Dictionary

tu′mor necro`sis fac`tor(n.)

  1. a protein, produced in humans and other animals, that is destructive to cells showing abnormally rapid growth.

    Category: Pharmacology, Biochemistry

    Ref: Abbr.: TNF

Origin of tumor necrosis factor:

1985–90

Princeton's WordNet

  1. tumor necrosis factor, tumour necrosis factor, TNF(noun)

    a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)

Wiktionary

  1. tumor necrosis factor(Noun)

    Any of several polypeptide hormones, produced by macrophages, that can destroy some cancer cells

Freebase

  1. Tumor necrosis factor alpha

    Tumor necrosis factor is an adipokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells and neurons. The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease, cancer, major depression and inflammatory bowel disease. While still controversial, studies of depression and IBD are currently being linked to TNF levels. Recombinant TNF is used as an immunostimulant under the INN tasonermin. TNF can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

Translation

Find a translation for the tumor necrosis factor definition in other languages:

Select another language:

Discuss these tumor necrosis factor definitions with the community:


Citation

Use the citation below to add this definition to your bibliography:

Style:MLAChicagoAPA

"tumor necrosis factor." Definitions.net. STANDS4 LLC, 2014. Web. 22 Jul 2014. <http://www.definitions.net/definition/tumor necrosis factor>.

Are we missing a good definition for tumor necrosis factor?


The Web's Largest Resource for

Definitions & Translations


A Member Of The STANDS4 Network


Nearby & related entries:

Alternative searches for tumor necrosis factor: