Definitions for tumor necrosis factor
This page provides all possible meanings and translations of the word tumor necrosis factor
Random House Webster's College Dictionary
tu′mor necro`sis fac`tor(n.)
a protein, produced in humans and other animals, that is destructive to cells showing abnormally rapid growth.
Category: Pharmacology, Biochemistry
Ref: Abbr.: TNF
Origin of tumor necrosis factor:
tumor necrosis factor, tumour necrosis factor, TNF(noun)
a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)
tumor necrosis factor(Noun)
Any of several polypeptide hormones, produced by macrophages, that can destroy some cancer cells
Tumor necrosis factor alpha
Tumor necrosis factor is an adipokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease, cancer, major depression and inflammatory bowel disease. While still controversial, studies of depression and IBD are currently being linked to TNF levels. Recombinant TNF is used as an immunostimulant under the INN tasonermin. TNF can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
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"tumor necrosis factor." Definitions.net. STANDS4 LLC, 2014. Web. 16 Sep. 2014. <http://www.definitions.net/definition/tumor necrosis factor>.