Definitions for transglutaminase
trans·g·lu·tam·i·nase

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1. transglutaminasenoun

   Any of a family of enzymes that catalyze the reaction of lysine and glutamine groups in proteins and have a function in blood coagulation

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1. Transglutaminase

   Transglutaminases are enzymes that in nature primarily catalyze the formation of an isopeptide bond between γ-carboxamide groups ( -(C=O)NH2 ) of glutamine residue side chains and the ε-amino groups ( -NH2 ) of lysine residue side chains with subsequent release of ammonia ( NH3 ). Lysine and glutamine residues must be bound to a peptide or a protein so that this cross-linking (between separate molecules) or intramolecular (within the same molecule) reaction can happen. Bonds formed by transglutaminase exhibit high resistance to proteolytic degradation (proteolysis). The reaction is Gln-(C=O)NH2 + NH2-Lys → Gln-(C=O)NH-Lys + NH3Transglutaminases can also join a primary amine ( RNH2 ) to the side chain carboxyamide group of a protein/peptide bound glutamine residue thus forming an isopeptide bond Gln-(C=O)NH2 + RNH2 → Gln-(C=O)NHR + NH3These enzymes can also deamidate glutamine residues to glutamic acid residues in the presence of water Gln-(C=O)NH2 + H2O → Gln-COOH + NH3Transglutaminase isolated from Streptomyces mobaraensis -bacteria for example, is a calcium-independent enzyme. Mammalian transglutaminases among other transglutaminases require Ca2+ ions as a cofactor.Transglutaminases were first described in 1959. The exact biochemical activity of transglutaminases was discovered in blood coagulation protein factor XIII in 1968.

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1. Transglutaminase

   A transglutaminase is an enzyme that catalyzes the formation of a covalent bond between a free amine group and the gamma-carboxamide group of protein- or peptide-bound glutamine. Such an enzyme is classified as EC 2.3.2.13. Bonds formed by transglutaminase exhibit high resistance to proteolytic degradation. Transglutaminases were first described in 1959. The exact biochemical activity of transglutaminases was discovered in blood coagulation protein factor XIII in 1968.

How to pronounce transglutaminase?

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Numerology

1. Chaldean Numerology

   The numerical value of transglutaminase in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of transglutaminase in Pythagorean Numerology is: 5

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Transglutaminase
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Transglutaminase
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=transglutaminase