What does tositumomab mean?
Definitions for tositumomab
tosi·tu·momab
This dictionary definitions page includes all the possible meanings, example usage and translations of the word tositumomab.
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Wiktionary
tositumomabnoun
A mouse monoclonal antibody intended to treat follicular lymphoma.
Wikipedia
Tositumomab
Tositumomab is a murine monoclonal antibody which targets the CD20 antigen produced in mammalian cell. It was combined with iodine-131 to produce a radiopharmaceutical for unsealed source radiotherapy, Iodine-131 Tositumomab (branded as Bexxar), for the treatment of non-Hodgkins lymphoma. It is classified as a IgG2a lambda antibody.The drug combination was developed by Corixa which was purchased by GlaxoSmithKline in 2005. It was sold for about $25,000 for one round of treatment. Bexxar competed with Zevalin, until the former's discontinuation in 2014.
Wikidata
Tositumomab
Tositumomab is a drug for the treatment of follicular lymphoma. It is an IgG2a anti-CD20 monoclonal antibody derived from immortalized mouse cells. Tositumomab is applied in a sequential infusion followed by iodine tositumomab, which is the same antibody covalently bound to the radionuclide iodine-131. ¹³¹I emits both beta and gamma radiation and decays with a half-life of 8 days. Clinical trials have established the efficacy of the tositumomab/iodine tositumomab regimen in patients with relapsed or chemotherapy/rituxan refractory follicular lymphoma. This drug combination is manufactured by Corixa. It sells in the U.S. under the trade name Bexxar. Bexxar was developed by Dr. Mark Kaminski and Dr. Richard Wahl. There is some evidence that it may cause a smaller decrease in platelet counts than ibritumomab tiuxetan does.
Numerology
Chaldean Numerology
The numerical value of tositumomab in Chaldean Numerology is: 7
Pythagorean Numerology
The numerical value of tositumomab in Pythagorean Numerology is: 4
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"tositumomab." Definitions.net. STANDS4 LLC, 2024. Web. 25 Apr. 2024. <https://www.definitions.net/definition/tositumomab>.
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